Comparative Hemodynamic Effects of Intravenous Digoxin and Enoximone in Severe Chronic Heart Failure
| Autor: | Ivano Cantelli, Gianni Casella, Daniele Bracchetti, Pier Camillo Pavesi, Gaetano Barbato |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Inotrope Digoxin medicine.medical_specialty Coronary Disease Digitalis Severity of Illness Index Ventricular Function Left Internal medicine medicine Humans Enoximone Pharmacology (medical) Phosphodiesterase inhibitor Hemodynamic effects Aged Inotropic agent Heart Failure Cross-Over Studies biology business.industry Hemodynamics Middle Aged biology.organism_classification medicine.disease Heart failure Anesthesia Chronic Disease Injections Intravenous Cardiology Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiology. 85:303-310 |
| ISSN: | 1421-9751 0008-6312 |
| DOI: | 10.1159/000176702 |
| Popis: | In order to compare the acute hemodynamic effects of digoxin (0.01 mg/kg) and enoximone (1 mg/kg), a phosphodiesterase inhibitor inotropic agent, in severe chronic congestive heart failure, 8 patients (male, mean age 56.7 years, sinus rhythm) were investigated with a randomized cross-over study. Peak effect of enoximone (30 min) in comparison to that of digoxin (90 min) resulted in a similar reduction of left-ventricular filling pressure (-27 vs. -28%) and mean pulmonary artery pressure (-23 vs. -24%). Pulmonary (-39 vs. -16%; p0.01) and systemic vascular resistance (-27 vs. -4%; p0.001) were significantly lowered by enoximone. Cardiac index (+30 vs. +6%; p0.001) and heart rate (+11 vs. -3%; p0.05) were increased significantly more by enoximone than by digoxin. Since enoximone resulted in an enhancement of cardiac performance greater than that produced by digoxin, enoximone could be a useful and powerful substitute for digoxin in the acute therapy of severe chronic congestive heart failure with sinus rhythm. |
| Databáze: | OpenAIRE |
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