Hairy Cell Leukemia Variant
| Autor: | Leah Hartung, Melissa H. Cessna, Sherrie L. Perkins, David W. Bahler, Sheryl R. Tripp |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Pathology medicine.medical_specialty Lymphocytosis Sialic Acid Binding Ig-like Lectin 2 Biology Immunophenotyping Antigens CD Lectins medicine Humans Hairy cell leukemia Splenic marginal zone lymphoma Aged Hairy Cell Leukemia Variant Aged 80 and over Leukemia Hairy Cell General Medicine Middle Aged Flow Cytometry medicine.disease Immunohistochemistry CD11c Antigen Antigens Differentiation B-Lymphocyte Leukemia medicine.anatomical_structure Splenic Tissue Female Bone marrow medicine.symptom Cell Adhesion Molecules Integrin alpha Chains |
| Zdroj: | American Journal of Clinical Pathology. 123:132-138 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1309/8qytyq1clqmhq9cl |
| Popis: | Hairy cell leukemia variant (HCL-V) is a poorly described, rare B-cell lymphoproliferative disorder typically positive for CD103 and CD11c, while lacking CD25. Splenic marginal zone lymphomas (SMZL) also have this unusual phenotype in 15% to 25% of cases, have other overlapping clinical or morphologic features, and are more common than HCL-V. The purpose of our study was to better characterize HCL-V and determine whether most cases could be distinguished from SMZL. Cases with an HCL-V phenotype were identified from our flow cytometry service, and 10 were selected for further study based on bone marrow or splenic tissue availability. All cases had cytologic features consistent with HCL-V, and 9 of 10 patients had lymphocytosis. Bone marrow involvement was mostly interstitial and/or sinusoidal without lymphoid nodules. Coexpression of preswitched with postswitched heavy chain isotypes, an unusual feature of HCL, was seen in 2 of 4 cases. This study better defines HCL-V and establishes that most cases do not represent SMZL. |
| Databáze: | OpenAIRE |
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