Immunogenicity of pneumococcal vaccination of patients with cochlear implants
| Autor: | Ralf Schubert, Stefan Zielen, Markus A. Rose, Volker Gall, Christiane Hey, Sandy Kujumdshiev |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Heptavalent Pneumococcal Conjugate Vaccine Adolescent Immunoglobulins Meningococcal Vaccines medicine.disease_cause Pneumococcal conjugate vaccine Cohort Studies Pneumococcal Vaccines Streptococcus pneumoniae medicine Immunology and Allergy Humans Prospective Studies Child business.industry Meningitis Pneumococcal Immunogenicity Vaccination Infant medicine.disease Pneumococcal polysaccharide vaccine Antibodies Bacterial Pneumococcal infections Infectious Diseases Cochlear Implants Child Preschool Immunology Female business Meningitis medicine.drug |
| Zdroj: | The Journal of infectious diseases. 190(3) |
| ISSN: | 0022-1899 |
| Popis: | Background. Pneumococcal meningitis is a rare but potentially fatal complication of cochlear implantation.Methods. A prospective study was conducted of the immunogenicity of pneumococcal vaccination in 174 patients with cochlear implants (CIs). The cohort was divided into groups of patients with impaired hearing due to meningitis (P 1 ), cranial malformations (P 2 ), or an unknown cause (P 3 ) and was stratified by age as follows: 5 years (A 3 ). We determined immunoglobulin (Ig) levels for IgG subclasses 1–4 and serum concentrations of antibodies against pneumococci before and 4–6 weeks after vaccination. Group A1 received the 7-valent pneumococcal conjugate vaccine (PCV-7), group A 2 received PCV-7 or the 23-valent pneumococcal polysaccharide vaccine (PPV-23), and group A 3 received PPV-23.Results. IgG, IgM, and IgG1 levels were significantly lower in group P 1 , compared with the other patient groups and with historic data for healthy control subjects, suggesting a decreased antibody response. Group P1 had lower levels of pneumococcal antibodies, compared with groups P2 and P3 before vaccination (P |
| Databáze: | OpenAIRE |
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