Cognitive performance, fatigue and event-related potentials in patients with clinically isolated syndrome
| Autor: | Ewa Gruszka, Małgorzata Bilińska, Edyta Dziadkowiak, Mieszko Zagrajek, Krzysztof Słotwiński, Anna Pokryszko-Dragan, Ryszard Podemski |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Young Adult 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Event-related potential medicine Humans Cognitive Dysfunction 030212 general & internal medicine Effects of sleep deprivation on cognitive performance Young adult Evoked Potentials Fatigue Clinically isolated syndrome business.industry Multiple sclerosis Neuropsychology Cognition General Medicine Middle Aged medicine.disease Female Surgery Neurology (clinical) Verbal memory business 030217 neurology & neurosurgery Demyelinating Diseases |
| Zdroj: | Clinical Neurology and Neurosurgery. 149:68-74 |
| ISSN: | 0303-8467 |
| DOI: | 10.1016/j.clineuro.2016.07.022 |
| Popis: | Objectives Cognitive impairment and fatigue are regarded as important aspects of multiple sclerosis. The aim of this study was to evaluate cognitive performance, the level of fatigue and parameters of event-related potentials (ERP) in patients diagnosed with clinically isolated syndrome (CIS). Patients and methods The study comprised 44 patients with CIS and 45 healthy controls. Cognitive performance was assessed using the Brief Repeatable Battery of Neuropsychological Tests (BRBNT), fatigue - using the Fatigue Severity Scale (FSS) and Modified Fatigue Impact Scale (MFIS). Auditory ERP were performed and the parameters of N200 and P300 components were analyzed. Neuropsychological and electrophysiological measures were referred to clinical and radiological features of the disease activity. Results Forty five% of patients failed in at least one test from BRBNT, mainly within the domains of memory and attention. In 18% of patients FSS corresponded with moderate or severe fatigue. The mean latency of N200 and P300 was significantly longer and amplitude of P300 was lower in those patients with CIS than in the controls. Significant correlations were found between the results of MFIS and tests evaluating verbal memory and attention, as well as between N200 latency and results of tests for verbal memory. Conclusions Cognitive performance and fatigue deserve attention from the earliest clinical stage of MS. Abnormalities of event-related potentials in CIS suggest early impact of the disease on functional neural networks. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect