Premorbid multivariate prediction of adult psychosis-spectrum disorder: A high-risk prospective investigation
| Autor: | Sarnoff A. Mednick, Holger J. Sørensen, Emily Kline, Jason Schiffman, Thomas Tsuji, Erik Lykke Mortensen, Nicole Jameson, Shana Dodge |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis Risk Assessment Article Predictive Value of Tests medicine Humans Spectrum disorder Longitudinal Studies Psychiatry Biological Psychiatry Retrospective Studies Neurologic Examination Psychiatric Status Rating Scales Analysis of Variance Retrospective cohort study medicine.disease Mental illness Psychiatry and Mental health Psychotic Disorders ROC Curve Schizophrenia Predictive value of tests Etiology Female Schizophrenic Psychology Risk assessment Psychology |
| Zdroj: | Schizophrenia Research. 168:74-78 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2015.07.014 |
| Popis: | Premorbid prediction of psychosis-spectrum disorders has implications for both understanding etiology and clinical identification. The current study used a longitudinal high-risk for psychosis design that included children of parents with schizophrenia as well as two groups of controls (children whose parents had no mental illness, and children with at least one parent with a non-psychotic psychiatric diagnosis). Premorbid neurological factors and an indication of social function, as measured when participants were 10–13 years of age, were combined to predict psychosis-spectrum disorders in adulthood. Through a combination of childhood predictors, the model correctly classified 82% (27 of 33) of the participants who eventually developed a psychosis-spectrum outcome in adulthood. With replication, multivariate premorbid prediction, including genetic risk, social, and neurological variables, could potentially be a useful complementary approach to identifying individuals at risk for developing psychosis-spectrum disorders. |
| Databáze: | OpenAIRE |
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