Relationship between Coagulase Toxin-Type and Drug Susceptibility in Staphylococcus aureus Strains Isolated in all the Japanese National University Hospitals
| Autor: | Katsuko Okuzumi, Hiroshi Ushioda, Toshibumi Otsuka, Hideo Igarashi, Hiroyoshi Kobayashi, Akio Kimura |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Coagulase
Staphylococcus aureus endocrine system Superantigens Strain (chemistry) Toxin Bacterial Toxins Microbial Sensitivity Tests General Medicine Enterotoxin Biology bacterial infections and mycoses medicine.disease_cause University hospital Microbiology Hospitals University Enterotoxins Japan medicine Superantigen Humans Methicillin Resistance Typing |
| Zdroj: | Journal of the Japanese Association for Infectious Diseases. 67:223-230 |
| ISSN: | 1884-569X 0387-5911 |
| DOI: | 10.11150/kansenshogakuzasshi1970.67.223 |
| Popis: | Drug susceptibility of 430 Staphylococcus aureus strains isolated in 1991 from clinical specimens at all of the Japanese national university hospitals was evaluated in relationship with the epidemiological markers, namely, coagulase typing, and staphylococcal enterotoxins (SE) and toxic shock syndrome toxin 1 (TSST-1) production. There were five major methicillin-resistant Staphylococcus aureus (MRSA) groups in all the 252 MRSA strains: coagulase-type II-SEC + TSST-1- producing strains (II-SEC + TSST-1): 34.5%; coagulase-type II-no toxin-producing strains (II-): 15.4%; coagulase-type IV-SEA-producing strains (IV-SEA): 10.3%; coagulase-type II-SEA + SEC + TSST-1- producing strains (II-SEA + SEC + TSST-1): 8.7%; and coagulase-type III-no toxin-producing strains (III-): 7.1%. II-SEA + SEC + TSST-1 group was highly resistant to OFLX, whereas half of the other strain groups were sensitive to OFLX. Seventy-eight percent of the IV-SEA group was sensitive to FMOX, but there was no sensitive strain to FMOX in the II-SEA + SEC + TSST-1 group. More than 50% of the IV-SEA, III- and II-groups were sensitive to IPM, while the II-SEC + TSST-1 and II-SEA + SEC + TSST-1 groups were highly resistant to IPM. The III- and II-groups showed very good sensitivity to MINO, but the sensitivity to it of the II-SEA + SEC + TSST-1 group was very low. All of the strain groups were sensitive to ST except for the IV-SEA group. These results may provide useful information in the choice of antibacterial agents for MRSA infection. |
| Databáze: | OpenAIRE |
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