Defective neutrophil function in patients with perennial allergic rhinitis
| Autor: | Nikolaos G. Papadopoulos, Nikolaos Trakas, Popi E. Lianou, Athanasios A. Fortis, J. Papavassiliou |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Perennial plant biology business.industry atopy Chemotaxis General Medicine medicine.disease Defective neutrophil function biology.organism_classification Gastroenterology In vitro perennial allergic rhinitis Atopy host defense neutrophils Internal medicine Healthy control Immunology Medicine Immunology and Allergy In patient business Candida albicans |
| Zdroj: | University of Manchester-PURE |
| ISSN: | 1323-8930 |
| DOI: | 10.1046/j.1440-1592.2001.00196.x |
| Popis: | In the present study, neutrophil functions were examined in vitro in 35 patients (15 men and 20 women; mean age 38 years) suffering from perennial allergic rhinitis. Adherence to nylon, serum chemotaxis and phagocytosis–bactericidal activity were assayed. A Candida albicans strain was used for the experiments of phagocytosis–bactericidal activity. Adherence to patients’ neutrophils was found in normal patients (22.6 ± 1.89%) and healthy controls (26.1 ± 1.59%; P > 0.05). In contrast, the chemotactic ability of the patients’ sera was inferior to that of healthy control patients (leucotactic index 20.25 ± 0.76 vs 28.04 ± 0.46μm, respectively; P < 0.0001). Patients’ neutrophils phagocytosed 102.77 ± 6.03 microorganisms per 100 cells, while controls phagocytosed 138.05 ± 7.60 microorganisms per 100 cells (P |
| Databáze: | OpenAIRE |
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