Seizure frequency discrepancy between subjective and objective ictal electroencephalography data in dogs
| Autor: | Sean G. Sanders, Fiona James, Veronique Sammut, Danielle Powers, Thomas Parmentier, Luis Gaitero, Andrea Fischer, Tricia Tai, Hannes Lohi, Stephanie Nykamp, Masayasu Ukai, Miguel A. Cortez, Franziska Wielaender, Tarja S. Jokinen |
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| Přispěvatelé: | Helsinki One Health (HOH), Hannes Tapani Lohi / Principal Investigator, Veterinary Genetics, Veterinary Biosciences, Biosciences, Departments of Faculty of Veterinary Medicine, Equine and Small Animal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
ABSENCE SEIZURES
Veterinary medicine ELECTRODES ictal PDs Standard Article 030204 cardiovascular system & hematology Electroencephalography Audiology 413 Veterinary science 0403 veterinary science Epilepsy 0302 clinical medicine Status Epilepticus PROPOSAL SF600-1100 AWAKE Dog Diseases Prospective Studies EEG UTILITY medicine.diagnostic_test 04 agricultural and veterinary sciences Standard Articles 3. Good health Neurology Ambulatory medicine.symptom CANINE electroencephalography medicine.medical_specialty 040301 veterinary sciences Status epilepticus paroxysmal discharges 03 medical and health sciences Dogs Seizures medicine Animals Ictal MYOCLONIC EPILEPSY General Veterinary business.industry OPERATIONAL CLASSIFICATION seizure underreporting phenomenon Retrospective cohort study medicine.disease Confidence interval Myoclonic epilepsy SMALL ANIMAL business |
| Zdroj: | Journal of Veterinary Internal Medicine Journal of Veterinary Internal Medicine, Vol 35, Iss 4, Pp 1819-1825 (2021) |
| Popis: | Background Many studies of epilepsy in veterinary medicine use subjective data (eg, caregiver-derived histories) to determine seizure frequency. Conversely, in people, objective data from electroencephalography (EEG) are mainly used to diagnose epilepsy, measure seizure frequency and evaluate efficacy of antiseizure drugs. These EEG data minimize the possibility of the underreporting of seizures, a known phenomenon in human epileptology. Objective To evaluate the correlation between reported seizure frequency and EEG frequency of ictal paroxysmal discharges (PDs) and to determine whether seizure underreporting phenomenon exists in veterinary epileptology. Animals Thirty-three ambulatory video-EEG recordings in dogs showing >= 1 ictal PD, excluding dogs with status epilepticus. Methods Retrospective observational study. Ictal PDs were counted manually over the entire recording to obtain the frequency of EEG seizures. Caregiver-reported seizure frequency from the medical record was categorized into weekly, daily, hourly, and per minute seizure groupings. The Spearman rank test was used for correlation analysis. Results The coefficient value (r(s)) comparing reported seizure to EEG-confirmed ictal PD frequencies was 0.39 (95% confidence interval [CI] = 0.048-0.64, P = .03). Other r(s) values comparing history against various seizure types were: 0.36 for motor seizures and 0.37 for nonmotor (absence) seizures. Conclusions and Clinical Importance A weak correlation was found between the frequency of reported seizures from caregivers (subjective data) and ictal PDs on EEG (objective data). Subjective data may not be reliable enough to determine true seizure frequency given the discrepancy with EEG-confirmed seizure frequency. Confirmation of the seizure underreporting phenomenon in dogs by prospective study should be carried out. |
| Databáze: | OpenAIRE |
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