Evaluation of nailfold videocapillaroscopic abnormalities in patients with systemic lupus erythematosus
| Autor: | Alfredo Lurati, A. Soldi, Flavio Fantini, Silvana Zeni, L. Meani, Francesca Ingegnoli |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Adolescent Video Recording Connective tissue Gastroenterology Severity of Illness Index Microscopic Angioscopy Pathogenesis Diagnosis Differential Systemic lupus erythematosus Rheumatology Internal medicine Severity of illness medicine Humans Lupus Erythematosus Systemic In patient skin and connective tissue diseases Child Videocapillaroscopy Nailfold Capillaroscopy Aged Retrospective Studies Lupus erythematosus business.industry Reproducibility of Results Retrospective cohort study Middle Aged medicine.disease Capillaries Settore MED/16 - Reumatologia medicine.anatomical_structure Nails Child Preschool Female Differential diagnosis business |
| Zdroj: | Journal of clinical rheumatology : practical reports on rheumaticmusculoskeletal diseases. 11(6) |
| ISSN: | 1076-1608 |
| Popis: | Objective: Nailfold capillaroscopy (NFC) has been shown to have a remarkable value in the differential diagnosis of connective tissue diseases. In fact, NFC patterns reflect the microvascular changes that may play a significant role in pathogenesis. The aims of this study were to determine in patients with systemic lupus erythematosus (SLE) the prevalence of NFC patterns, to evaluate any association with clinical features and laboratory parameters. Materials and Methods: One hundred twenty-three patients with SLE were included in this retrospective study. Video NFC parameters were analyzed in each patient. In all cases, the following parameters were evaluated: capillary arrangement, density, size, and shape. Results: In patients with SLE, major capillary abnormalities were frequently observed (44 of 123 35.8%); however, no specific pattern was noted. There was a significant correlation between the SLEDAI index and the severity of capillary abnormalities (P 0.0001). Pathologic capillary abnormalities were also significantly increased in SLE with positive anti-U1-RNP antibodies (P 0.05). Conclusion: NFC may be a useful method to evaluate the microvascular changes in patients with SLE, and the presence of major capillary abnormalities seems to herald a more severe clinical course of the illness. |
| Databáze: | OpenAIRE |
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