Adiponectin, body mass index and hepatic steatosis are independently associated with IGF-I status in obese non-diabetic women
| Autor: | Carmen Barbu, Anca Sirbu, Alice Albu, S. Gologan, Simona Fica, I. Pirvulescu, Sorina Martin, Tudor Arbanas, Catalin Copaescu |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Body Mass Index Diabetes Complications Young Adult Endocrinology Insulin resistance Internal medicine Medicine Humans Obesity Insulin-Like Growth Factor I Aged Adiponectin biology business.industry Insulin Quantitative insulin sensitivity check index C-reactive protein Middle Aged medicine.disease Fatty Liver Cross-Sectional Studies biology.protein Body Composition Female Steatosis Insulin Resistance business Body mass index |
| Zdroj: | Growth hormoneIGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 23(1-2) |
| ISSN: | 1532-2238 |
| Popis: | Low IGF-I levels have been associated with obesity, insulin resistance, hepatic steatosis, and were shown to predict cardiovascular mortality. Adiponectin, on the other hand, was proved to have an important protective role against metabolic and cardiovascular diseases. This study investigates the relation between hepatic steatosis, adiponectin and IGF-I levels in a group of non-diabetic obese Romanian women.This cross-sectional study included 201 obese non-diabetic women, with mean age of 41.1±11.9 years and mean body mass index (BMI) of 44.1±8.3 kg/m(2), consecutively admitted to the Endocrinology Department of a University Hospital to be evaluated as candidates for bariatric surgery. Main measured parameters included total adiponectin (detected by ELISA method), insulin, C reactive protein (CRP), and IGF-I (all by chemiluminescence methods). Insulin sensitivity was assessed using the Quantitative Insulin Sensitivity Check Index (QUICKI). Patients were considered IGF-deficient if IGF-I z score was ≤2 standard deviations from mean for age. Hepatic ultrasound was used to determine the presence of significant steatosis (SS+).Significant steatosis was observed in 60.7% of our patients and this feature was associated with reduced total adiponectin levels (p0.001) and lower IGF-I z scores (p0.001). IGF-I z score negatively correlated with BMI (r=-0.283, p0.001), alanine aminotransferase (ALT) (r=-0.130, p=0.032), gamma glutamyltransferase (GGT) (r=-0.158, p=0.018) and logarithmic transformed (log) CRP (r=-0.232, p=0.001) and positively correlated with QUICKI (r=0.148, p=0.023) and log adiponectin (r=0.216, p=0.003). The relationship between IGF-I z score and log adiponectin remained significant after adjusting for age, BMI, ALT, QUICKI and log CRP (r=0.183, p=0.012). IGF-I deficiency was present in 33.3% of these obese women. In multivariate logistic analysis, BMI (p0.001), ALT (p=0.003), log adiponectin (p0.001) and SS (p=0.043) proved to be independently associated with IGF-I deficiency.Adiponectin is significantly correlated with IGF-I z scores and, along with BMI, ALT and significant steatosis, is independently associated with IGF-I deficiency in obese non-diabetic women. |
| Databáze: | OpenAIRE |
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