Target definition in salvage postoperative radiotherapy for prostate cancer: 18F-fluorocholine PET/CT assessment of local recurrence

Autor: Philippe Robin, Olivier Pradier, David Bourhis, Antoine Valeri, J.-P. Malhaire, Ulrike Schick, N. Rosenfelder, Georges Fournier, Ronan Abgral, Osman El Kabbaj, Gurvan Dissaux, Pierre-Yves Salaun
Přispěvatelé: Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Service de médecine nucléaire [Brest], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Hôpital Morvan [Brest], CHRU de Brest, service de chirurgie urologique et de la transplantation reinale (CHU - BREST - Urologie), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), CHRU Brest - Service de médecine nucléaire (CHU - BREST - Med Nucléaire), Laboratoire de Traitement de l'Information Medicale (LaTIM), Institut National de la Santé et de la Recherche Médicale (INSERM)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), CHRU Brest - Service de radiothérapie (CHU - BREST - Radiothérapie), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut Brestois Santé Agro Matière (IBSAM)
Rok vydání: 2017
Předmět:
Male
Biochemical recurrence
Fluorine Radioisotopes
[SDV]Life Sciences [q-bio]
medicine.medical_treatment
[SDV.CAN]Life Sciences [q-bio]/Cancer
[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine
Anastomosis
Choline
030218 nuclear medicine & medical imaging
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Positron Emission Tomography Computed Tomography
medicine
Humans
Radiology
Nuclear Medicine and imaging
ComputingMilieux_MISCELLANEOUS
Aged
Retrospective Studies
Salvage Therapy
PET-CT
medicine.diagnostic_test
business.industry
Prostatic Neoplasms
Retrospective cohort study
Hematology
General Medicine
Middle Aged
medicine.disease
3. Good health
Radiation therapy
Oncology
Positron emission tomography
030220 oncology & carcinogenesis
Cohort
Radiotherapy
Adjuvant
Neoplasm Recurrence
Local
Radiopharmaceuticals
business
Nuclear medicine
Zdroj: Acta Oncologica
Acta Oncologica, Taylor & Francis, 2017, 57 (3), pp.375-381
ISSN: 1651-226X
0284-186X
Popis: Purpose: Inadequate clinical target volume (CTV) definition is likely to be a major contributing factor to local recurrence (LR) rate after radiotherapy. Our aims were to identify sites of prostate cancer LR in biochemical recurrence post-prostatectomy using 18F-Fluorocholine (18F-FCH) positron emission tomography/computed tomography (PET/CT) and to compare different CTV-delineation guidelines in a cohort of postoperative patients.Material and methods: Thirty-six patients presenting with LR within the prostatic bed on 18F-FCH PET/CT between 10/2011 and 06/2016 were included in this retrospective study. Median PSA at the time of 18F-FCH PET/CT was 2.7 ng/mL (0.8–9.4) and median PSA doubling time was 11 months (3–28). For each patient, the CTVRTOG, CTVFROGG and CTVEORTC following the corresponding guidelines were outlined and compared. Forty-one LR were delineated using a gradient-based method and the percentage of FCH uptake included in each CTV was evaluated.Results: The anastomosis was the most c...
Databáze: OpenAIRE
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