Musculoskeletal Responses to Exercise Plus Nutrition in Men with Prostate Cancer on Androgen Deprivation: A 12-Month RCT
| Autor: | Niamh L Mundell, Stephen Foulkes, Steve F. Fraser, Timo Rantalainen, Declan G. Murphy, Jeremy Millar, Robin M. Daly, Patrick J. Owen, Jack Dalla Via, Patricia M. Livingston |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty muscle lihakset Physical Therapy Sports Therapy and Rehabilitation androgen deprivation therapy bone law.invention ravinto Androgen deprivation therapy Prostate cancer Randomized controlled trial Bone Density law Internal medicine medicine cancer Humans Orthopedics and Sports Medicine Muscle Strength Vitamin D Adverse effect Aged Femoral neck Bone mineral luusto exercise syöpähoidot eturauhassyöpä kuntoliikunta business.industry Prostatic Neoplasms Androgen Antagonists medicine.disease Confidence interval Exercise Therapy Calcium Dietary nutrition Whey Proteins medicine.anatomical_structure Dietary Supplements Body Composition Lean body mass Patient Compliance syöpätaudit business Biomarkers |
| Zdroj: | Medicine & Science in Sports & Exercise. 53:2054-2065 |
| ISSN: | 1530-0315 0195-9131 |
| Popis: | PURPOSE Androgen deprivation therapy (ADT) for prostate cancer has multiple adverse effects on musculoskeletal health. This 12-month randomized controlled trial aimed to assess the effects of multicomponent exercise training combined with whey protein, calcium and vitamin D supplementation on bone mineral density (BMD), structure and strength, body composition, muscle strength, and physical function in ADT-treated men. METHODS Seventy ADT-treated men were randomized to exercise plus supplementation (Ex + Suppl; n = 34) or usual care (control; n = 36). Ex + Suppl involved thrice weekly progressive resistance training plus weight-bearing impact exercise with daily multinutrient supplementation. Primary outcomes were DXA hip and spine areal BMD. Secondary outcomes included the following: tibia and radius pQCT volumetric BMD, bone structure and strength, DXA body composition, pQCT muscle and fat cross-sectional area and muscle density, and muscle strength and physical function. RESULTS Sixty men (86%) completed the study. Mean exercise and supplement adherence were 56% and 77%, respectively. There were no effects of the intervention on bone or body composition outcomes. Ex + Suppl improved leg muscle strength (net difference, (95% confidence interval, or CI), 14.5% (-0.2 to 29.2); P = 0.007) and dynamic mobility (four-square-step test time, -9.3% (-17.3 to -1.3), P = 0.014) relative to controls. Per-protocol analysis of adherent participants (≥66% exercise, ≥80% supplement) showed Ex + Suppl preserved femoral neck aBMD (1.9% (0.1 to 3.8), P = 0.026) and improved total body lean mass (1.0 kg (-0.23 to 2.22), P = 0.044) relative to controls. CONCLUSIONS Exercise training combined with multinutrient supplementation had a limited effect on ameliorating the adverse musculoskeletal consequences of ADT, likely related to the modest intervention adherence. |
| Databáze: | OpenAIRE |
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