Impact of tuberculosis in children with idiopathic nephrotic syndrome
| Autor: | Udai Kala, Thomson Pd, Lawrence S. Milner, David W. C. Jacobs |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Nephrology
medicine.medical_specialty Nephrotic Syndrome Tuberculosis medicine.medical_treatment Black People Renal function Kidney Function Tests urologic and male genital diseases Gastroenterology South Africa chemistry.chemical_compound Internal medicine Prevalence medicine Humans Renal replacement therapy Child Tuberculosis Pulmonary Creatinine Glomerulosclerosis Focal Segmental urogenital system business.industry Nephrosis Lipoid Glomerulosclerosis medicine.disease female genital diseases and pregnancy complications Endocrinology chemistry Child Preschool Pediatrics Perinatology and Child Health business Nephrotic syndrome Negroid |
| Zdroj: | Pediatric Nephrology. 7:392-395 |
| ISSN: | 1432-198X 0931-041X |
| Popis: | Forty black South African children (mean age 4.7 +/- 2.6 years) with idiopathic nephrotic syndrome due to focal glomerulosclerosis (FSGS) were evaluated. Tuberculosis (TB) was found in 37.5% of children with FSGS (FSGS-TB) compared with 6% of a comparable group with minimal lesion nephrotic syndrome. No significant differences were found in the initial mean serum albumin, cholesterol, triglyceride and creatinine levels in FSGS-TB compared with children with glomerulosclerosis but without TB (FSGS-nonTB). The mean serum levels of C4, IgA and IgM were increased by 30%, 25% and 23%, respectively in children with FSGS-TB compared with FSGS-nonTB. Initial estimated creatinine clearance was similar in the two groups, but after a mean follow-up of 2.4 years, the mean estimated creatinine clearance of children with FSGS-TB was significantly reduced by 46% from the initial value, but remained stable in the FSGS-nonTB group. FSGS-TB children also had significantly increased requirements for renal replacement therapy compared with children with FSGS-nonTB. We conclude that TB infection is commonly associated with FSGS in black South African children; this may have deleterious effects on renal function. |
| Databáze: | OpenAIRE |
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