Pain, psychoaffective symptoms, and quality of life in human T cell lymphotropic virus type 1 (HTLV-1): a cross-sectional study
| Autor: | Kionna Oliveira Bernardes Santos, Dislene Nascimento dos Santos, Rosana Andrade, Fernanda Costa de Queirós, Janine Ribeiro Camatti, Alaí Barbosa Paixão, Abrahão Fontes Baptista, Katia Nunes Sá |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Neurology T-Lymphocytes Asymptomatic 03 medical and health sciences Cellular and Molecular Neuroscience Myelopathy 0302 clinical medicine Quality of life immune system diseases Virology Internal medicine Tropical spastic paraparesis medicine Humans Human T cell lymphotropic virus type 1 Human T-lymphotropic virus 1 business.industry Chronic pain virus diseases medicine.disease Paraparesis Tropical Spastic 030104 developmental biology Cross-Sectional Studies Neuropathic pain Quality of Life Neurology (clinical) medicine.symptom Chronic Pain business 030217 neurology & neurosurgery |
| Zdroj: | Journal of neurovirologyReferences. 27(6) |
| ISSN: | 1538-2443 |
| Popis: | The objective of this study is to describe the chronic pain characteristics in individuals infected with human T cell lymphotropic virus type 1 (HTLV-1) per subgroup (asymptomatic, oligosymptomatic, and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)) compared with controls with chronic pain without HTLV-1. This is a cross-sectional study investigating associations between pain profile, psychopathological symptoms, and quality of life. Individuals infected with HTLV-1 refer high-intensity pain compared with controls, with more severe characteristics being present in oligosymptomatic and HAM/TSP individuals. Oligosymptomatic individuals have a tendency of diffuse and frequent pain, mainly in the head/neck region and more depressive symptoms, resembling nociplastic pain. Neuropathic pain was localized in the lower limbs in all infected groups, worse in HAM/TSP individuals, and associated with a worse perception of quality of life. Pain was associated to higher levels of TNF-alpha and interferon-gamma. HTLV-1 pain is generally more severe when compared with other chronic pain syndromes, being present mainly in the lower limbs. Certain characteristics are typical, depending on the affected group. Oligosymptomatic and HAM/TSP individuals present more diffuse pain, with higher intensity and greater impact in quality of life. Increased levels of inflammatory cytokines are associated with HTLV-1-related pain. |
| Databáze: | OpenAIRE |
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