Possibility of using combined transplantation of multipotent mesenchymal stromal cells and hepatic stellate cells to activate reparative liver regeneration in mature and old organism
Autor: | Dmitry Grebnev, Victoria Vakhrusheva, Ekaterina Petrunina, Irina Maklakova |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Programmed cell death Pathology medicine.medical_specialty Environmental Engineering Stromal cell lcsh:QP1-981 Regeneration (biology) Mesenchymal stem cell lcsh:QR1-502 Biology lcsh:Microbiology lcsh:Physiology Industrial and Manufacturing Engineering Liver regeneration Transplantation 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis lcsh:Zoology Hepatic stellate cell medicine lcsh:QL1-991 Intracellular |
Zdroj: | BIO Web of Conferences, Vol 22, p 01004 (2020) |
ISSN: | 2117-4458 |
Popis: | The aim of the study was to examine the effect of combined transplantation of multipotent mesenchymal stromal (MMSC) and hepatic stellate (HSC) cells on liver regeneration after resection. Research has been carried out on laboratory animals of mature and old age. After the subtotal resection of the liver, MMSC and HSC were introduced in the tail vein in the amount of 4 million cl/kg of body weight and 9 million cl/kg of body weight respectively. Evaluation of reparative liver regeneration was performed on the 1st, 3rd, 7th days after subtotal liver resection. Features of reparative liver regeneration in mature and old organism were revealed. In mature organism against the background of combined cell transplantation, regeneration activation is achieved by increasing cellular and intracellular regeneration mechanisms. In this case, the old organism responds to cell transplantation by activating only intracellular mechanisms. In both age groups, decreased mutagenesis and inhibition of programmed cell death against the background of MMSC cotransplantation and HSC were observed. |
Databáze: | OpenAIRE |
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