Amine-modified kaolinite clay preserved thyroid function and renal oxidative balance after sub-acute exposure in rats
| Autor: | Adewale Adewuyi, Chiagoziem A. Otuechere, Beatrice O Fadoju, Ebunoluwa P Olajide, Oghenetega J. Avwioroko |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Physiology Potassium Thyroid Gland chemistry.chemical_element 010501 environmental sciences Calcium Kidney complex mixtures 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Internal medicine Drug Discovery medicine Animals Amines Kaolin 030304 developmental biology 0105 earth and related environmental sciences Pharmacology 0303 health sciences Triiodothyronine Thyroid Albumin General Medicine Rats Oxidative Stress Thyroxine medicine.anatomical_structure Endocrinology chemistry Clay Uric acid Thyroid function |
| Zdroj: | Journal of Basic and Clinical Physiology and Pharmacology. 32:89-96 |
| ISSN: | 2191-0286 0792-6855 2019-0298 |
| Popis: | Objectives Kaolinite clay is an abundant natural resource in Nigeria with several industrial applications. Incidentally, the wide-scale use of kaolinite clay is hampered by its small surface area. The objective of this study was to assess the effects of amine-modified clay on electrolyte, thyroid, and kidney function markers. Methods Modification of kaolinite clay with an amine functional group was achieved using surface grafting technique. Characterization with a scanning electron microscope and Brunauer-Emmett Teller surface area analyzer confirmed this modification. However, there is sparse information on the effect of amine-modified kaolinite clay on electrolyte homeostasis, thyroid, and renal function. Rats were administered amine-modified kaolinite clay at the doses of 1, 2, and 5 mg/kg body weight. Results After 14 days of repeated-dose treatment, there were no significant changes in levels of albumin, uric acid, triiodothyronine, thyroxine, ratio of triiodothyronine to thyroxine, and relative kidney organ weight. Furthermore, there were no changes in the concentration of potassium, although amine-modified kaolinite clay significantly decreased sodium, calcium, and total cholesterol levels. Amine-modified kaolinite clay, at all treatment doses, also preserved the renal histoarchitecture and oxidative balance in rats. Conclusions This study reports on the effect of amine-modified kaolinite clay on renal markers and thyroid function, and further deepens our understanding of their biochemical action. This baseline data may boost the prospect of using amine-modified kaolinite clay in the treatment of contaminated water. |
| Databáze: | OpenAIRE |
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