Mutation induction and neoplastic transformation in human and human-hamster hybrid cells: dependence on photon energy and modulation in the low-dose range
| Autor: | M. Frankenberg-Schwager, Wolfgang Göhde, E. Pralle, Daniela Uthe, Burkhard Greve, Erhard Severin, D. Frankenberg, I. Garg |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Hypoxanthine Phosphoribosyltransferase
Hamster CD59 Antigens Hybrid Cells Photon energy Radiation Dosage 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Relative biological effectiveness Animals Humans Neoplastic transformation Irradiation Waste Management and Disposal Cell Line Transformed Physics business.industry X-Rays Low dose Public Health Environmental and Occupational Health Gamma ray Dose-Response Relationship Radiation General Medicine Fibroblasts Molecular biology Cell Transformation Neoplastic Gamma Rays 030220 oncology & carcinogenesis Mutation Nuclear medicine business Relative Biological Effectiveness Mutation induction |
| Zdroj: | Journal of Radiological Protection. 22:A17-A20 |
| ISSN: | 0952-4746 |
| DOI: | 10.1088/0952-4746/22/3a/303 |
| Popis: | Mutation induction in the HPRT gene of human fibroblasts after irradiation with mammography-like 29 kVp or 200 kVp x-rays shows radiohypersensitivity for doses smaller than approximately 0.5 Gy. Similarly, mutation induction in the CD 59 gene on human chromosome 11 in A(L) cells shows radiohypersensitivity for doses smaller than approximately 0.5 Gy after exposure to 200 kVp x-rays, but not after irradiation with low-filtered 30 kVp x-rays. The RBE values of 29 and 30 kVp x-rays relative to 200 kVp x-rays are strongly dose dependent. For neoplastic transformation of human hybrid (CGL1) cells after irradiation with 29 or 200 kVp x-rays or 60Co gamma rays a linear-quadratic dose relationship was observed with RBE values of approximately four and eight for mammography relative to 200 kVp x-rays and 60Co gamma rays, respectively. |
| Databáze: | OpenAIRE |
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