Once-daily theophylline in the treatment of nocturnal asthma
Autor: | K Sahlström, P Brander, A Hakulinen, V. Vilkka, P Karttunen, M. Silvasti, E Aalto, J. Laitinen |
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Rok vydání: | 1990 |
Předmět: |
Adult
Male Evening Adolescent medicine.drug_class Terbutaline Peak Expiratory Flow Rate Drug Administration Schedule Random Allocation Double-Blind Method Theophylline Bronchodilator Humans Medicine Pharmacology (medical) Circadian rhythm Aged Morning Asthma Pharmacology business.industry Standard treatment General Medicine Middle Aged medicine.disease Delayed-Action Preparations Anesthesia Female business medicine.drug |
Zdroj: | European Journal of Clinical Pharmacology. 39:241-243 |
ISSN: | 1432-1041 0031-6970 |
Popis: | The efficacy and side-effects of individually adjusted doses of controlled-release theophylline given once daily in the evening (average dose 650 mg) were compared with those of standard treatment with controlled-release terbutaline 7.5 mg b.d. Thirty-six asthmatics with regular morning obstruction ("morning dipping") were studied over two treatment periods each of two weeks, according to a crossover, randomized, double blind design. Morning peak expiratory flow (PEF) was slightly but significantly higher with theophylline (363 l.min-1) than terbutaline (342 l.min-1). Feelings of dyspnoea on waking in the morning were also less pronounced with theophylline. There were no other differences between the treatment periods during the day or night, with respect to dyspnoea or any the other symptoms. Side-effects were mild and were reported with similar frequencies during both treatments. It is concluded than an individually adjusted dose of once-daily theophylline administered in the evening is at least as effective as conventional therapy with controlled-release terbutaline in preventing nocturnal and early morning asthma, when both drugs are added to regular medication with inhaled sympathomimetics and steroids. |
Databáze: | OpenAIRE |
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