FUNCTIONAL ASSESSMENT OF HUMAN GASTROINTESTINAL-TRACT USING TC-99 M-LATEX PARTICLES
| Autor: | Bekdik Cf, Erhan Pişkin, Biray Caner, Gunaydin Erbengi, Kapucu Lo, Meral T. Ercan, S.A. Tuncel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Latex Transit time Gastroenterology Caecum Digestive System Physiological Phenomena Reference Values Internal medicine Healthy volunteers medicine Humans Radiology Nuclear Medicine and imaging Gastrointestinal Transit Radionuclide Imaging biology Gastric emptying business.industry Human gastrointestinal tract Technetium Sigmoid colon General Medicine Middle Aged biology.organism_classification Microspheres medicine.anatomical_structure Oral ingestion Abdomen Female Nuclear medicine business Digestive System |
| Popis: | Tc-99-m-latex particles (LP) is a newly developed radiopharmaceutical for the evaluation of the gastrointestinal (GI) tract. Following oral ingestion, it passes through the entire GI tract undissolved. The purpose of the present investigation was to introduce the clinical application of Tc-99-m-LP. A group of 11 healthy volunteers was studied. Following a 12 h fast, the subjects were given 150 ml of water containing 37 MBq of Tc-99-m-LP orally. Dynamic images up to 2 h were recorded to document temporal progression of radioactivity. Static images of the abdomen and whole body were taken at intervals. In normal subjects the tracer arrival times at the caecum and sigmoid colon were 3.2 +/- 0.9 and 11.2 +/- 3.2 h, respectively. The average t1/2 value for gastric emptying, 50% colonic filling and small bowel transit time were found to be 21.6 +/- 5.6, 233 +/- 72 and 211 +/- 66.4 min, respectively. In conclusion, Tc-99-m-LP has the potential of providing functional information of the GI tract. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|