Spontaneously hypertensive rat (SHR) as an animal model for ADHD: a short overview
| Autor: | Teresa Ponce-Lopez, Ruth Tellez, C. Castillo, Alfredo Meneses, Andrea Gallegos-Cari, Georgina Perez-Garcia |
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| Rok vydání: | 2011 |
| Předmět: |
Serial reaction time
Memory Disorders Methylphenidate General Neuroscience Dysfunctional family Water maze Rats Inbred WKY Open field Rats Developmental psychology Disease Models Animal Animal model Spontaneously hypertensive rat Attention Deficit Disorder with Hyperactivity Rats Inbred SHR mental disorders medicine Animals Humans Passive avoidance Cognition Disorders Psychology Neuroscience medicine.drug |
| Zdroj: | revneuro. 22:365-371 |
| ISSN: | 2191-0200 0334-1763 |
| DOI: | 10.1515/rns.2011.024 |
| Popis: | Diverse studies indicate that attention-deficit hyperactivity disorder (ADHD) is associated with alterations in encoding processes, including working or short-term memory. Some ADHD dysfunctional domains are reflected in the spontaneously hypertensive rat (SHR). Because ADHD, drugs and animal models are eliciting a growing interest, hence the aim of this work is to present a brief overview with a focus on the SHR as an animal model for ADHD and memory deficits. Thus, this paper reviews the concept of SHR as a model system for ADHD, comparing SHR, Wistar-Kyoto and Sprague-Dawley rats with a focus on the hypertension level and working, short-term memory and attention in different behavioral tasks, such as open field, five choice serial reaction time, water maze, passive avoidance, and autoshaping. In addition, drug treatments (d-amphetamine and methylphenidate) are evaluated. |
| Databáze: | OpenAIRE |
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