Werner syndrome as a possible cause of non-alcoholic steatohepatitis
| Autor: | Masatomo Mori, Ken Sato, Shinichi Kiso, Takeshi Kashihara, Hiroaki Hashizume, Hitoshi Takagi, Daisuke Kanda |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Biopsy Disease digestive system Pathology and Forensic Medicine Liver disease Insulin resistance Fibrosis Medicine Humans Werner syndrome Anthropometry business.industry Liver cell nutritional and metabolic diseases General Medicine medicine.disease digestive system diseases Fatty Liver Liver Female Laparoscopy Werner Syndrome Steatosis Steatohepatitis business |
| Zdroj: | Journal of clinical pathology. 62(11) |
| ISSN: | 1472-4146 |
| Popis: | Non-alcoholic steatohepatitis (NASH) is characterised by steatosis, liver cell injuries, the presence of a mixed inflammatory lobular infiltrate, and variable degrees of fibrosis. Werner syndrome (WS) is a rare autosomal recessive disease characterised by the premature onset of multiple age-related disorders. Central obesity and insulin resistance are common symptoms of both NASH and WS. Three cases were studied to evaluate the association between WS and NASH. NASH was diagnosed by liver biopsies and imaging studies following the exclusion of alcohol consumption, viral disease or autoimmune liver disease. Liver histology was compatible with NASH in all cases. Liver dysfunction, hyperlipidaemia, insulin resistance and regional increase of intra-abdominal fat even though the body mass indices were all normal or low, were observed. Metabolic disorders due to WS may complicate and cause NASH. Hence, the observed clinical association between WS and NASH suggests that patients with WS should also be screened for NASH. |
| Databáze: | OpenAIRE |
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