Serum protein mediators of dementia and aging proper
| Autor: | Safa Al-Rubaye, Ram J. Bishnoi, Raymond F. Palmer, Donald R. Royall |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Apolipoprotein E cognition Male medicine.medical_specialty Aging functional status 03 medical and health sciences 0302 clinical medicine Von Willebrand factor Internal medicine medicine Dementia Humans Allele Psychiatry Aged biology Cognition Cell Biology intelligence Middle Aged medicine.disease Somatomedin Blood proteins 030104 developmental biology Endocrinology biology.protein Female Psychology 030217 neurology & neurosurgery Hormone Research Paper |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | The latent variable "δ" (for "dementia") appears to be uniquely responsible for the dementing aspects of cognitive impairment. Age, depressive symptoms, gender and the apolipoprotein E (APOE) e4 allele are independently associated with δ. In this analysis, we explore serum proteins as potential mediators of age's specific association with δ in a large, ethnically diverse longitudinal cohort, the Texas Alzheimer's Research and Care Consortium (TARCC). 22 serum proteins were recognized as partial mediators of age's association with δ. These include Insulin-like Growth Factor-Binding Protein 2 (IGF-BP2), which we had previously associated with age-specific cognitive change, and both Pancreatic Polypeptide (PP) and von Willebrand Factor (vWF), previously associated with δ. Nine other δ-related proteins were not confirmed by this ethnicity adjusted analysis. Our findings suggest that age's association with the disabling fraction of cognitive performance is partially mediated by serum proteins, somatomedins and hormones. Those proteins may offer targets for the specific treatment of age-related effects on dementia severity and conversion risk. |
| Databáze: | OpenAIRE |
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