Prevalence of human papillomavirus in Jeddah, Saudi Arabia
| Autor: | Anwar M. Hashem, Sawsan S. Al-amri, Ahmed M. Tolah, Ahmed A. Mirza, Hassan S. Abduljabbar, Ayman Oraif, Hanin H. Abduljabbar, Manar Mousa, Esam I. Azhar, Afnan A. Degnah |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Adolescent Cross-sectional study viruses Saudi Arabia MEDLINE lcsh:Medicine Enzyme-Linked Immunosorbent Assay 030209 endocrinology & metabolism Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Seroepidemiologic Studies Genotype Prevalence Humans Medicine 030212 general & internal medicine Papillomaviridae Human papillomavirus Young adult Aged biology business.industry lcsh:R Papillomavirus Infections Age Factors virus diseases General Medicine Middle Aged biology.organism_classification Virology Cross-Sectional Studies Original Article Female business |
| Zdroj: | Annals of Saudi Medicine Annals of Saudi Medicine, Vol 39, Iss 6, Pp 403-409 (2019) |
| ISSN: | 0975-4466 0256-4947 |
| DOI: | 10.5144/0256-4947.2019.403 |
| Popis: | BACKGROUND: Human papillomaviruses (HPVs) are small, non-enveloped, double-stranded DNA viruses that consist of more than 200 genotypes. Low-risk genotypes are associated with warts or benign lesions, whereas high-risk genotypes are usually associated with malignancies and cancers including cervical cancer. However, the real prevalence and incidence of HPV in Saudi Arabia may be understated due to a lack of comprehensive data reporting. OBJECTIVES: Determine the positivity rate of HPV in men and women in Jeddah, Saudi Arabia. DESIGN: Cross-sectional. SETTING: Tertiary care center in Jeddah. SUBJECTS AND METHODS: Self-collected vaginal swab samples were obtained from females attending the gynecological clinic in the period between October 2017 and April 2018 at a tertiary care center, Jeddah, Saudi Arabia. PCR-positive HPV samples were sequenced to determine genotype. Additionally, serum samples were collected from healthy male and female blood donors and screened for HPV IgG antibodies by ELISA. MAIN OUTCOME MEASURES: Molecular and serological positivity for HPV. SAMPLE SIZE: 119 self-collected vaginal swabs from females at a gynecology clinic and 966 serum samples from healthy blood donors. RESULTS: Of the 119 tested vaginal swabs, 7 samples (5.9%) were positive for HPV DNA. Several genotypes were identified. Most of the positive samples were from Saudi females in the age range of 31-50 years seeking care for infertility. Of the 966 serum samples, only 16 samples (1.7%) were positive for HPV IgG antibodies. CONCLUSION: While the prevalence of HPV in men and women in our sample from the western region of Saudi Arabia was low, our data clearly show that it is not uncommon among high-risk groups and people are still exposed to the risk of HPV infection. Most importantly, these data provide valuable information that could aid in enhancing national awareness about HPV and in introducing an HPV vaccination program. LIMITATIONS: Single hospital and a convenience sample CONFLICT OF INTEREST: None. |
| Databáze: | OpenAIRE |
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