Hypoxia in Fetal Lambs: A Study with 1H-NMR Spectroscopy of Cerebrospinal Fluid
| Autor: | Udo F. H. Engelke, Henk W. Jongsma, Jane Crevels, Ron A. Wevers, Berend Oeseburg, Anne-Marie van Cappellen van Walsum, Roel Nijland, Sytske H. Moolenaar, Jan G. Nijhuis |
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| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Fetus Magnetic Resonance Spectroscopy Sheep Phenylalanine Hypoxia (medical) Lactic acid Fetal Diseases chemistry.chemical_compound Cerebrospinal fluid Endocrinology chemistry Pregnancy Internal medicine Pediatrics Perinatology and Child Health medicine Animals Choline Female Protons medicine.symptom Hypoxia Hypoxanthine Acidosis |
| Zdroj: | Pediatric Research. 49:698-704 |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | In fetal lambs, severe hypoxia (SH) will lead to brain damage. Mild hypoxia (MH) is thought to be relatively safe for the fetal brain because compensating mechanisms are activated. We questioned whether MH, leading to mild acidosis, induces changes in cerebral metabolism. Metabolites in cerebrospinal fluid (CSF) samples, as analyzed by proton magnetic resonance spectroscopy, were studied in two groups of seven anesthetized near-term fetal lambs. In group I, SH leading to acidosis with an arterial pH |
| Databáze: | OpenAIRE |
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