The COX-2 rs20417 Polymorphism and Risk of Coronary Artery Disease: Evidence from 17,621 Subjects
| Autor: | Wenbin Wu, Miao Zhang, Yu Fu, Wang Heng, Guoheng Zhang, Dong Liu, Cunjiang Li, Zhang Hui, Shijiang Yang |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine PubMed medicine.medical_specialty Subgroup analysis Coronary Artery Disease Gastroenterology Coronary artery disease Asian People Risk Factors Internal medicine medicine Humans Genetics Polymorphism Genetic Models Genetic business.industry Knowledge infrastructure Odds ratio medicine.disease Confidence interval Cyclooxygenase 2 Meta-analysis Female Dominant model Cardiology and Cardiovascular Medicine business Systematic search |
| Zdroj: | Heart, Lung and Circulation. 23:572-577 |
| ISSN: | 1443-9506 |
| DOI: | 10.1016/j.hlc.2014.01.002 |
| Popis: | Background The Cyclooxygenase-2 (COX-2) rs20417 polymorphism has been implicated in coronary artery disease (CAD) risk, but individually published studies have shown inconsistent results. The aim of this study was to clarify the effects of COX-2 rs20417 polymorphism on CAD risk. Methods A systematic literature search up to October 27, 2013 was carried out in PubMed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) databases, and the references of retrieved articles were screened. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were analysed for co-dominant model (CC vs. GG), additive model (C vs. G), dominant model (CC+GC vs. GG), and recessive model (CC vs. GG+GC) to assess the association using fixed- or random-effect model. Results We identified nine articles (10 case-control studies) that included 3,439 cases and 14,182 controls for the present meta-analysis. Significant association between COX-2 rs20417 polymorphism and risk of CAD was observed in co-dominant model (OR=0.64, 95% CI=0.43-0.95, p =0.026) and recessive model (OR=0.77, 95% CI=0.61-0.97, p =0.025). Moreover, in the subgroup analysis stratified by ethnicity, significant associations were observed in Asians (OR=0.28, 95% CI=0.13–0.61, p =0.001 for CC vs. GC+GG; OR=0.24, 95% CI=0.11–0.51, p Conclusions These results suggest that COX-2 rs20417 polymorphism may contribute to CAD development, especially in Asians. |
| Databáze: | OpenAIRE |
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