Profile of BAFF and its receptors’ expression in lupus nephritis is associated with pathological classes
| Autor: | Carlos A. Cañas, Fabio E. Ospina, C A Jiménez, Juan Naranjo-Escobar, Iván Posso-Osorio, A Sánchez, Gabriel J. Tobón, Juan-Pablo Suso |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Biopsy Transmembrane Activator and CAML Interactor Protein Cell Lupus nephritis Kidney Severity of Illness Index Pathogenesis 03 medical and health sciences 0302 clinical medicine stomatognathic system Rheumatology immune system diseases hemic and lymphatic diseases B-Cell Activating Factor Humans Medicine Prospective Studies B-Cell Maturation Antigen skin and connective tissue diseases Receptor B-cell activating factor Pathological 030203 arthritis & rheumatology business.industry Antigens CD20 medicine.disease Immunohistochemistry Lupus Nephritis stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Immunology business Biomarkers B-Cell Activation Factor Receptor |
| Zdroj: | Lupus. 27:708-715 |
| ISSN: | 1477-0962 0961-2033 |
| Popis: | Background/Objective B-cell activating factor (BAFF) plays an important role in the pathogenesis of systemic lupus erythematosus. However, the role of BAFF in lupus nephritis (LN) is not understood. Our aim was to evaluate the expression of BAFF and its three receptors in renal biopsy samples from patients with LN and investigate a relationship with pathological class. Methods We conducted a prospective descriptive study (2011-2014) on 52 kidney biopsy samples from patients with LN. Immunohistochemistry for BAFF, its receptors (transmembrane activator and calcium modulator and cyclophilin ligand interaction (TACI), protein maturation of B cells (BCMA), and BAFF-receptor (BAFF-R)), and CD20 expression was performed. Samples were scored according to the percentage of cells with positive expression. Results In class II LN, BAFF-R and TACI were not expressed, whereas BCMA and BAFF were lowly expressed in the interstitial inflammatory infiltrates. Proliferative class III/IV had elevated BAFF expression in the glomeruli, and TACI was expressed in interstitial inflammatory infiltrates and the glomeruli. Interestingly, the class IV cases with vasculopathy ( n = 4) had endothelial BAFF expression, which was not visible in thrombotic microangiopathy ( n = 4). Class V was characterized by low BAFF expression in interstitial inflammatory infiltrates and by BAFF, TACI, and BCMA expression in the glomeruli. BAFF expression was associated with inflammatory scores and CD20 positive infiltrates, mainly in class IV. Conclusions Expression patterns of BAFF and its receptors differ according to LN class. Our study provides evidence that BAFF could be used as a routine marker in LN biopsies and to determine which patients will benefit from anti-BAFF therapy. |
| Databáze: | OpenAIRE |
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