Perioperative Hemodynamic Optimization in Patients at Risk for Delirium – A Randomized-Controlled Trial
| Autor: | Kristina E. Fuest, Ariane Servatius, Bernhard Ulm, Stefan J. Schaller, Bettina Jungwirth, Manfred Blobner, Sebastian Schmid |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Frailty
Therapieerfolg Delirium Emergence delirium Therapy General Medicine post-operative delirium Medicine outcome goal-directed hemodynamic monitoring goal-directed therapy frailty ddc Alter <70-90 Jahre> Prevention and control Hemodynamic monitoring ddc:610 Treatment outcome Postoperative Phase Hämodynamische Untersuchung Gebrechlichkeit Therapie Aged |
| Zdroj: | Frontiers in Medicine. 9 |
| ISSN: | 2296-858X |
| DOI: | 10.3389/fmed.2022.893459 |
| Popis: | BackgroundPost-operative delirium is common in elderly patients and associated with increased morbidity and mortality. We evaluated in this pilot study whether a perioperative goal-directed hemodynamic optimization algorithm improves cerebral oxygenation and can reduce the incidence of delirium.Materials and MethodsPatients older than 70 years with high risk for post-operative delirium undergoing elective non-cardiac surgery were randomized to an intervention or control group. Patients in the intervention group received a perioperative hemodynamic optimization protocol based on uncalibrated pulse-contour analysis. Patients in the control group were managed according to usual standard of care. Incidence of delirium until day seven was assessed with confusion assessment method (CAM) and chart review. Cerebral oxygenation was measured with near-infrared spectroscopy.ResultsDelirium was present in 13 of 85 (15%) patients in the intervention group and 18 of 87 (21%) in the control group [risk difference −5.4%; 95% confidence interval, −16.8 to 6.1%; P = 0.47]. Intervention did not influence length of stay in hospital or in-hospital mortality. Amounts of fluids and vasopressors applied, mean arterial pressure, cardiac index, and near-infrared spectroscopy values were comparable between groups.ConclusionThe hemodynamic algorithm applied in high-risk non-cardiac surgery patients did not change hemodynamic interventions, did not improve patient hemodynamics, and failed to increase cerebral oxygenation. An effect on the incidence of post-operative delirium could not be observed.Clinical Trial Registration[Clinicaltrials.gov], identifier [NCT01827501]. |
| Databáze: | OpenAIRE |
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