Na+/H+ exchange during an oral glucose challenge in patients with essential hypertension
| Autor: | Martin Tepel, Spieker C, B Frye, Zidek W, J Ruhwinkel, M Burchardt |
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| Rok vydání: | 1998 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Sodium-Hydrogen Exchangers Time Factors Endocrinology Diabetes and Metabolism Sodium medicine.medical_treatment chemistry.chemical_element Essential hypertension chemistry.chemical_compound Endocrinology Cytosol In vivo Internal medicine medicine Humans Insulin Lymphocytes Pancreatic hormone Cells Cultured Glucose tolerance test Analysis of Variance medicine.diagnostic_test C-Peptide Chemistry C-peptide Glucose Tolerance Test Hydrogen-Ion Concentration medicine.disease Blood pressure Glucose Hypertension Female |
| Zdroj: | The Journal of endocrinology. 155(3) |
| ISSN: | 0022-0795 |
| Popis: | To determine the effects of an oral glucose challenge on cellular Na+/H+ exchange in vivo we measured plasma glucose concentrations, plasma insulin concentrations, plasma C-peptide concentrations, arterial blood pressure, cytosolic pH (pHi) and cellular Na+/H+ exchange in 24 patients with essential hypertension (HT) and 41 age-matched healthy normotensive control subjects (NT) during a standardized oral glucose tolerance test. Under resting conditions, the plasma glucose concentrations, plasma insulin concentrations, plasma C-peptide concentrations and Na+/H+ exchange activity were significantly higher in HT compared with NT (P < 0.05 in each case). A significant increase in lymphocytic Na+/H+ exchange activity was only seen in NT (resting 0 h: (4.23 +/- 0.2) x 10(-3) pHi/s; mean +/- S.E.M.; 1 h after glucose administration: (6.00 +/- 0.56) x 10(-3) pHi/s; 2 h after glucose administration: (6.65 +/- 0.64) x 10(-3) pHi/s; P = 0.0003 by Friedman's two-way ANOVA), but not in HT (resting 0 h: (6.07 +/- 0.36) x 10(-3) pHi/s; 1 h after glucose administration: (6.72 +/- 1.02) x 10(-3) pHi/s; 2 h after glucose administration: (6.71 +/- 0.62) x 10(-3) pHi/s; P = 0.7470). During an oral glucose challenge the systolic (P < 0.0001) and diastolic (P < 0.0001) blood pressure significantly decreased in HT but not in NT. Essential hypertension shows abnormal in vivo regulation of Na+/H+ exchange and blood pressure following oral glucose intake. |
| Databáze: | OpenAIRE |
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