Processing of potential upper respiratory tract probiotics by spray drying
| Autor: | Géraldine Broeckx, Filip Kiekens, Sarah Lebeer, Ilke De Boeck, Dieter Vandenheuvel, Camille Nina Allonsius, Katarina Jokicevic |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
biology business.industry medicine.drug_class General Chemical Engineering Antibiotics 04 agricultural and veterinary sciences 02 engineering and technology biology.organism_classification 040401 food science Gastroenterology 0404 agricultural biotechnology medicine.anatomical_structure 020401 chemical engineering Lactobacillus Spray drying Internal medicine medicine Microbiome 0204 chemical engineering Physical and Theoretical Chemistry business Respiratory tract |
| Zdroj: | Drying technology |
| ISSN: | 1532-2300 0737-3937 |
| Popis: | To shorten the duration of upper respiratory tract (URT) diseases or reduce the symptoms alternative treatments to antibiotics and decongestants are needed, due to their side effects and frequent failure. Recent human microbiome research has led to the hypothesis that beneficial bacteria, capable of colonizing the human URT, could constitute an interesting approach to prevent and reduce URT diseases. Since probiotics are live microorganisms with a beneficial effect on the host, it is important that the probiotic bacteria are delivered at the site of action, without hampering their viability. Here, the formulation applicability of eight new probiotic candidates belonging to the Lactobacillus genus was evaluated after spray drying. Besides viability, growth and fermentation abilities after drying were confirmed through experiments. A promising strain was chosen for further optimization. Microscopic visualization and flow cytometry of bacterial morphology identified spray drying as a suitable processing method. Adhesion experiments indicated no changes in functionality. Lastly, the contact time between bacteria and hot drying air was identified as a crucial parameter in spray drying of probiotics. |
| Databáze: | OpenAIRE |
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