On normalizing of urinary KIM-1 level to urine creatinine in patients with renal cell cancer
| Autor: | K. Yu. Kanukoev, I. I. Alentov, T A Karmakova, Andrey Kaprin, N. V. Marshutina, N. S. Sergeeva |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Urinary system Urology Urine Urinalysis Renal cell carcinoma medicine Humans In patient Carcinoma Renal Cell business.industry Biochemistry (medical) Acute kidney injury General Medicine Acute Kidney Injury Urine Creatinine medicine.disease Kidney Neoplasms Medical Laboratory Technology Quartile Creatinine Female Cell cancer business Biomarkers |
| Zdroj: | Russian Clinical Laboratory Diagnostics. 66:517-524 |
| ISSN: | 2412-1320 0869-2084 |
| DOI: | 10.51620/0869-2084-2021-66-9-517-524 |
| Popis: | KIM-1 (kidney injury molecule 1), a marker of acute kidney injury, is produced by epithelial cells of renal proximal tubules. Elevated KIM-1 levels in urine and plasma are associated with renal cell carcinoma (RCC). The aim of this study was to compare the significance of non-normalized uKIM-1 values and those normalized to urine creatinine, as urinary biomarkers in RCC. The uKIM-1, urine creatinine and their ratio (uKIM-1/Cre) were studied in 118 RCC patients and 58 apparently healthy subjects. The median of uKIM-1 in the healthy group was 0.71 ng/ml (1st and 3rd quartiles were 0.35 and 1.23, respectively) and in RCC patients it was 2.36 (1.43; 5.93) ng/ml. The medians of uKIM-1/Cre were 0.77 (0.49; 1.18) and 2.42 (1.41; 4.61) ng/mgCre, respectively. Stage I RCC is statistically significantly different from stages II-III and stage IV using uKIM-1/Cre values (p = 0.0056 and p = 0.0012, respectively); using uKIM-1 values significant differences occur only when comparing stages I and IV (p = 0.015). In both healthy individuals and RCC patients, uKIM-1/Cre levels were slightly lower in subgroups younger than 50 years than in subgroups older than 50 years, whereas a similar trend was observed for uKIM-1 only in patients. In healthy men and male patients, uKIM-1 levels were higher than in the corresponding groups of women (the differences were not statistically significant), but the use of uKIM-1/Cre values eliminated the gender differences. A high correlation was found between the concentrations of uKIM-1 and urine creatinine in three healthy subjects followed up for 3 weeks (Spearman’s correlation coefficients were 0.758, 0.825 and 0.933, respectively). The data obtained are clear evidence of the need for normalization uKIM-1 to urine creatinine in RCC patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|