A Malva parviflora´s fraction prevents the deleterious effects resulting from neuroinflammation
| Autor: | Enrique Jiménez-Ferrer, Cristina E. Ramírez-Serrano, Gustavo Pedraza-Alva, Alejandro Zamilpa, Ricardo Jair Ramírez-Carreto, Maribel Herrera-Ruiz, Jaime Tortoriello, Leonor Pérez-Martínez, Gabriela Vargas-Villa, Anahí Chavarría |
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| Rok vydání: | 2019 |
| Předmět: |
Lipopolysaccharides
Sitosterol 3-O-β-D-glucopyranoside 0301 basic medicine LPS Central nervous system Anti-Inflammatory Agents RM1-950 Disease Pharmacology Malva parviflora NF-κB Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Neuroinflammation Memory medicine Animals Cognitive deficit Inflammation Malva biology Plant Extracts business.industry Macrophages Brain General Medicine medicine.disease biology.organism_classification Astrogliosis 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Therapeutics. Pharmacology medicine.symptom business |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 118, Iss, Pp-(2019) |
| ISSN: | 0753-3322 |
| Popis: | Neuroinflammation, a centralized immune response, is a physiological process by which the organism attempts to remove an injurious stimulus in the central nervous system. Nonetheless, it is known that chronic inflammatory processes play an important role in the onset and progression of neurodegenerative disorders, such as Alzheimer´s disease (AD). Based on this, new strategies to treat AD have been proposed. Among them, the use of non-steroidal anti-inflammatory drugs (NSAIDs) decreases the incidence of this disease. Unfortunately, the prolonged use of NSAIDs results in adverse secondary effects. In this context, plants secondary metabolites have become of great interest. Particularly, our group has demonstrated that the hydroalcoholic extract of Malva parviflora (MpHA) has anti-inflammatory effect and is capable of improving the cognitive deficit present in an AD model. To further characterize the Malva parviflora compounds with anti-inflammatory properties, here we generated a fraction from a dichloromethane extract, which constitutes a less complex mix of compounds than the MpHA. This approach allowed us to isolate a fraction (MpF10) with anti-inflammatory activity, able to ameliorate the spatial learning and memory impairment, and to reduce both astrogliosis as well as IL-1β and TNF production in a murine model of LPS-mediated neuroinflammation. Among the identified compounds in the MpF10, we found daucosterol (MpDau), which prevented LPS-induced neuroinflammation. Interestingly, MpF10 and MpDau inhibit NFκB activity in macrophages exposed to LPS. Therefore, we propose that the compounds present in the MpF10 represent an alternative to treat neuroinflammation, an important process developed during neurodegenerative diseases such as AD. |
| Databáze: | OpenAIRE |
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