Effect of serum concentration on the cytotoxicity and sister chromatid exchange induction by a chemical carcinogen and by a diesel particulate extract in V79 hamster cells
| Autor: | Hélène M. Coulomb, Marie-Paule Loireau, Ivan Chouroulinkov, Z.W. Gu |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Cancer Research
Methylnitronitrosoguanidine Cell Survival Hamster Sister chromatid exchange Biology Cell Line Toxicology Diesel fuel Cricetulus Cricetinae Cytotoxic T cell Animals Crossing Over Genetic Cytotoxicity Lung Particulates Serum concentration Molecular biology Blood Petroleum Oncology Toxicity Carcinogens Automobiles Sister Chromatid Exchange Cell Division Fuel Oils |
| Zdroj: | Cancer letters. 22(1) |
| ISSN: | 0304-3835 |
| Popis: | The role of serum concentration on the cytotoxicity and on the sister chromatid exchange (SCE)-induction by N -methyl- N′ -nitro- N -nitrosoguanidine (MNNG) and by a diesel particulate extract (DPE), a complex mixture, has been carried out on V79 cells. An increase of the serum concentration in the medium decreases the toxicity of these chemicals, and especially when they are dispersed first in serum. Although no influence of serum concentration on the number of spontaneous SCEs occurring in control cells has been observed, the increase of serum concentration leads to a decrease in SCE's induction in treated cells. Our results show that serum can protect cells from the cytotoxic and mutagenic action of MNNG and diesel extract. |
| Databáze: | OpenAIRE |
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