Use of the Crustacean Artemia franciscana for Alternative Biotests
| Autor: | Alena Havelková, Michal Žďárský, Petr Dvořák, Zbyněk Sklenář Ph.D, Katarína Beňová |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Pharmacotoxicology
chemistry.chemical_element 010501 environmental sciences Cadmium chloride 01 natural sciences Toxicology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine pharmacotoxicology Ecotoxicology Potassium dichromate 0105 earth and related environmental sciences Cadmium lcsh:Veterinary medicine General Veterinary biology irradiation synergy effects biology.organism_classification Ascorbic acid Crustacean Artemia salina chemistry Biochemistry 030220 oncology & carcinogenesis lcsh:SF600-1100 |
| Zdroj: | Acta Veterinaria Brno, Vol 79, Iss 9, Pp 47-53 (2010) |
| ISSN: | 1801-7576 0001-7213 |
| Popis: | Use of the crustacean Artemia franciscana for alternative biotests of the second generation was studied, and possible experimental design and applications of such tests outlined. In addition to the classical use in ecotoxicology, the test can be used in pharmacology as well, or to monitor the effects of ionizing radiation in co-exposure with some chemical compounds. The synergistic effect of co-exposure of PCB (DELOR 103), cadmium chloride and potassium dichromate with beta 89Sr irradiation was shown. We also demonstrated the anti-oxidative and pro-oxidative effects of the ascorbic acid in dependence on its concentration. Use of the pharmaco-toxicological screening in search for the novel inhibitors of cyclin-dependent kinases was demonstrated as well, showing that Artemia franciscana may be used as a suitable biosensor instead of the expensive tests on higher vertebrates. |
| Databáze: | OpenAIRE |
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