Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment
| Autor: | Jianxin Mai, Izabela Podgorski, Michael L. Cher, Dora Cavallo-Medved, Mansoureh Sameni, Kamiar Moin, Bonnie F. Sloane, Julie Dosescu, Shiqing Yan, Bruce E. Linebaugh |
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| Rok vydání: | 2005 |
| Předmět: |
Cancer Research
Proteases Endothelial cells Cathepsin D Cathepsin E Cell Communication Cathepsin B Mice Cathepsin O stromal elements Neoplasms Cathepsin L1 Animals Humans Bone Biology Cathepsin S Cathepsin Cysteine proteases Chemistry Life Sciences Inflammatory cells Cell biology Biochemistry Stromal Cells |
| Zdroj: | Biological Sciences Publications |
| ISSN: | 1044-579X |
| DOI: | 10.1016/j.semcancer.2004.08.001 |
| Popis: | Tumor-stromal interactions induce expression of matrix metalloproteinases and serine proteases and, as shown recently, the cysteine protease cathepsin B. We speculate that such interactions upregulate the transcription factor Ets1, resulting in increased cathepsin B expression. This would be consistent with the observed concomitant upregulation of matrix metalloproteinases and serine proteases as well as with the ability of extracellular matrices and their binding partners to alter cathepsin B expression and secretion. Using a confocal assay to analyze the contribution of tumor-stromal interactions to proteolysis, we have been able to confirm enhanced degradation of extracellular matrices by all three classes of proteases. |
| Databáze: | OpenAIRE |
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