Radiotherapy and immunotherapy: Can this combination change the prognosis of patients with melanoma brain metastases?
| Autor: | F. De Rose, Piera Navarria, Davide Franceschini, Armando Santoro, Ciro Franzese, M. Del Vecchio, A.M. Ascolese, Marta Scorsetti |
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| Rok vydání: | 2016 |
| Předmět: |
Oncology
medicine.medical_specialty Skin Neoplasms Metastatic melanoma medicine.medical_treatment Antineoplastic Agents Radiosurgery 03 medical and health sciences 0302 clinical medicine Immune system Internal medicine Medicine Humans Radiology Nuclear Medicine and imaging In patient Melanoma business.industry Brain Neoplasms Antibodies Monoclonal General Medicine Immunotherapy Chemoradiotherapy Radiotherapy alone medicine.disease Prognosis Preclinical data Ipilimumab Radiation therapy Nivolumab 030220 oncology & carcinogenesis business 030217 neurology & neurosurgery |
| Zdroj: | Cancer treatment reviews. 50 |
| ISSN: | 1532-1967 |
| Popis: | Brain metastases are a common occurrence in patients with melanoma. Prognosis is poor. Radiotherapy is the main local treatment for brain metastases. Recently, immunotherapy (i.e. immune checkpoints inhibitors) showed a significant impact on the prognosis of patients with metastatic melanoma, also in the setting of patients with brain metastases. Despite various possible treatments, survival of patients with melanoma brain metastases is still unsatisfactory; new treatment modalities or combination of therapies need to be explored. Being immunotherapy and radiotherapy alone both efficient in the treatment of melanoma brain metastases, the combination of these two therapies seems logical. Moreover radiotherapy can improve the efficacy of immunotherapy and the immune system plays a relevant role in the action of radiotherapy. Preclinical data support this combination. Clinical data are more contradictory. In this review, we will discuss available therapies for melanoma brain metastases, focusing on the preclinical and clinical available data supporting the possible synergism between radiotherapy and immunotherapy. |
| Databáze: | OpenAIRE |
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