Predictors for Poststroke Outcomes: The Tel Aviv Brain Acute Stroke Cohort (TABASCO) Study Protocol
| Autor: | Hermona Soreq, Ludmila Shopin, Noomi Katz, Nir Giladi, Talma Hendler, Natan M. Bornstein, Itzhak Shapira, Sali Usher, Shani Shenhar-Tsarfaty, Jeffrey M. Hausdorff, Dafna Ben Baashat, Zahava Solomon, Orna Aizenstein, Amos D. Korczyn, Anat Mike, Einor Ben Assayag, Efrat Kliper, Eitan Auriel, A. Sholmo Berliner, Hen Hallevi, Uri Goldbourt |
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| Rok vydání: | 2011 |
| Předmět: |
Genetic Markers
Male medicine.medical_specialty Psychological intervention Physical medicine and rehabilitation Neuroimaging Risk Factors medicine Humans Dementia Prospective Studies Prospective cohort study Stroke Depression (differential diagnoses) Aged Neurologic Examination business.industry Cognition Middle Aged Prognosis medicine.disease Neurology Ischemic Attack Transient Sample Size Cohort Female Nervous System Diseases Cognition Disorders business Magnetic Resonance Angiography Stress Psychological |
| Zdroj: | International Journal of Stroke. 7:341-347 |
| ISSN: | 1747-4949 1747-4930 |
| DOI: | 10.1111/j.1747-4949.2011.00652.x |
| Popis: | Background Recent studies have demonstrated that even survivors of mild stroke experience residual damage, which persists and in fact increases in subsequent years. About 45% of stroke victims remain with different levels of disability. Identifying factors associated with poststroke cognitive and neurological decline could potentially yield more effective therapeutic opportunities. Aims and hypothesis We hypothesize that data based on biochemical, neuroimaging, genetic and psychological measures can, in aggregate, serve as better predictors for subsequent disability, cognitive and neurological deterioration, and suggest possible interventions. Design The Tel-Aviv Brain Acute Stroke Cohort (TABASCO) study is an ongoing, prospective cohort study that will recruit approximately 1125 consecutive first-ever mild–moderate stroke patients. It is designed to evaluate the association between predefined demographic, psychological, inflammatory, biochemical, neuroimaging and genetic markers, measured during the acute phase, and long-term outcome: subsequent cognitive deterioration, vascular events (including recurrent strokes), falls, affect changes, functional everyday difficulties and mortality. Discussion This study is an attempt to comprehensively investigate the long-term outcome of mild–moderate strokes. Its prospective design will provide quantitative data on stroke recurrence, the incidence of other vascular events and the evaluation of cognitive, affective and functional decline. Identifying the factors associated with poststroke cognitive and functional decline could potentially yield more effective therapeutic approaches. |
| Databáze: | OpenAIRE |
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