Immunologic, endocrine and psychological influences on cortisol-induced immunoglobulin synthesis in vitro
| Autor: | Ad J. J. M. Vingerhoets, Rudy E. Ballieux, Hugo J. Duivenvoorden, Lea Jabaaij, R. J. Benschop, Frank G. Oostveen |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone Endocrinology Diabetes and Metabolism Lymphocyte Immunoglobulin E Peripheral blood mononuclear cell Monocytes Endocrinology Internal medicine medicine Endocrine system Humans Secretion Biological Psychiatry Cells Cultured biology Dose-Response Relationship Drug Endocrine and Autonomic Systems Psychoneuroimmunology Psychiatry and Mental health medicine.anatomical_structure Immunoglobulin M Immunoglobulin G Immunology biology.protein Female Antibody Psychology Arousal Glucocorticoid medicine.drug |
| Zdroj: | Psychoneuroendocrinology. 18(8) |
| ISSN: | 0306-4530 |
| Popis: | In the present study, the relationship between psychological variables and hydrocortisone (HC)-induced immunoglobulin (Ig) production in vitro was investigated. Ninety-five human volunteers were selected based on their extreme (low or high) scores on a daily hassles and a symptoms questionnaire. Four groups were composed: (1) few hassles, few symptoms; (2) many hassles, few symptoms; (3) few hassles, many symptoms; and (4) many hassles, many symptoms. Incubating peripheral blood mononuclear cells (PBMC) for 2 weeks with HC (concentrations ranging from 10 −8 to 10 −6 M), resulted in a concentration-dependent rise in IgM and IgG secretion. In vitro IgM as well as IgG secretion were found to be related to plasma Ig levels. Plasma cortisol levels were positively associated with HC-induced IgG secretion. Furthermore, Ig secretion was found to depend on psychological profile, indicating a differential sensitivity of PBMC to HC for the four groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|