Estimating the association between being seropositive for cysticercosis and the prevalence of epilepsy and severe chronic headaches in 60 villages of rural Burkina Faso

Autor:	Ida Sahlu, Cici Bauer, Pierre Dorny, Zekiba Tarnagda, Rasmané Ganaba, Athanase Millogo, Assana Cissé, Veronique Dermauw, Sarah Gabriël, Pierre-Marie Preux, Hélène Carabin
Přispěvatelé:	Department of Epidemiology [Brown University School of Public Health], Brown University School of Public Health -Brown University, Department of Biostastistics and Epidemiology [University of Oklahoma Health Sciences Center], University of Oklahoma (OU)-University of Oklahoma Health Sciences Center (OUHSC), Agence de Formation de Recherche et d'expertise en Santé pour l'Afrique (AFRICSanté), Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Institut de Recherche en Sciences de la Santé Bobo Dioulasso (INSSA), Université Polytechnique Nazi Boni Bobo-Dioulasso (UNB), Research Group Veterinary Public Health and Zoonoses, Department of Veterinary Public Health and Food Safety, Laboratorium of Chemical Analysis, Universiteit Gent = Ghent University [Belgium] (UGENT), Department of Biomedical Sciences [Antwerp], Institute of Tropical Medicine [Antwerp] (ITM), Department of Biostatistics [Houston], MD Anderson Cancer Center [Houston], The University of Texas Health Science Center at Houston (UTHealth)- The University of Texas Health Science Center at Houston (UTHealth), Centre Hospitalier Universitaire Souro Sanou [Bobo-Dioulasso] (CHUSS), Grelier, Elisabeth, Brown University-Brown University School of Public Health, Universiteit Gent = Ghent University (UGENT)
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Male Rural Population Swine Cross-sectional study Health Care Providers RC955-962 Social Sciences Pathology and Laboratory Medicine MESH: Neurocysticercosis 0302 clinical medicine Sociology MESH: Rural Population Surveys and Questionnaires MESH: Child Arctic medicine. Tropical medicine MESH: Animals Child Mammals Aged 80 and over Schools MESH: Middle Aged Eukaryota 3. Good health medicine.drug_formulation_ingredient Neurology MESH: Young Adult MESH: Epilepsy Public aspects of medicine BURDEN medicine.medical_specialty Headache Disorders DIAGNOSIS Education 03 medical and health sciences Signs and Symptoms MESH: Cross-Sectional Studies Physicians Taenia solium Humans Migraine MESH: Prevalence Aged MESH: Adolescent MESH: Taenia solium Epilepsy MESH: Humans ILAE Organisms Public Health Environmental and Occupational Health Biology and Life Sciences MESH: Adult Odds ratio Tropical Diseases medicine.disease Health Care Cross-Sectional Studies MESH: Randomized Controlled Trials as Topic 030104 developmental biology Food Antigens Helminth Population Groupings MESH: Female 0301 basic medicine Pediatrics Medical Doctors Neurocysticercosis NEUROCYSTICERCOSIS MESH: Aged 80 and over Animal Products Epidemiology Prevalence Medicine and Health Sciences EPIDEMIOLOGY Pork Medical Personnel Randomized Controlled Trials as Topic MESH: Aged Headaches Agriculture Cysticercosis Middle Aged COMMUNITY Professions Infectious Diseases MIGRAINE Helminth Infections Vertebrates Female medicine.symptom RA1-1270 Research Article Neglected Tropical Diseases Adult Meat Adolescent 030231 tropical medicine MESH: Antigens Helminth Young Adult Diagnostic Medicine Burkina Faso parasitic diseases Parasitic Diseases medicine Animals MESH: Burkina Faso MESH: Surveys and Questionnaires Nutrition business.industry MESH: Male Diet [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie People and Places Amniotes MESH: Headache Disorders [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business
Zdroj:	PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0007101 (2019) PLoS Neglected Tropical Diseases PLoS Neglected Tropical Diseases, Public Library of Science, 2019, 13 (1), pp.e0007101. ⟨10.1371/journal.pntd.0007101⟩ PLOS NEGLECTED TROPICAL DISEASES PLoS Neglected Tropical Diseases, 2019, 13 (1), pp.e0007101. ⟨10.1371/journal.pntd.0007101⟩
ISSN:	1935-2735 1935-2727
DOI:	10.1371/journal.pntd.0007101⟩
Popis:	Background Individuals diagnosed with neurocysticercosis often present with epilepsy and sometimes with progressively worsening severe chronic headaches (WSCH). While cross-sectional associations between seropositivity to cysticercal antigens and epilepsy have been reported, few large scale studies have been conducted in West Africa and none have measured the association between seropositivity to cysticercal antigens and headaches. This study aimed at filling these knowledge gaps by estimating the strength of the cross-sectional association between seropositivity to cysticercal antigens and the prevalence of epilepsy and WSCH in 60 villages of Burkina Faso, West Africa. Methodology/Principal findings Baseline data from a cluster randomized controlled trial collected from January 2011 to February 2012 in 60 villages across three provinces in Burkina Faso were used. Between 78 and 80 individuals were screened for epilepsy and WSCH in each village, and those screened positive were confirmed by a physician. Seventy-five percent of all participants were asked to provide a blood sample to test for Taenia solium cysticercus circulating antigens. Hierarchical multivariable logistic models were used to measure the association between seropositivity to cysticercal antigens and epilepsy (lifetime and active) as well as WSCH. Among 3696 individuals who provided a blood sample, 145 were found to have epilepsy only, 140 WSCH only and 19 both. There were positive associations between seropositivity to cysticercal antigens and active epilepsy (prevalence odds ratio (POR): 2.40 (95%CI: 1.15–5.00)) and WSCH (POR: 2.59 (1.34–4.99)). Conclusions/Significance Our study is the first to demonstrate a cross-sectional association between seropositivity to cysticercal antigens and WSCH in a large community-based study conducted in West Africa. The measured cross-sectional association had a strength similar to the ones previously observed between seropositivity to cysticercal antigens and lifetime or active epilepsy. As a result, preventing new cysticercosis cases in communities may reduce the prevalence of these two important neurological disorders. Author summary Taenia solium is a parasite that can be transmitted between humans and pigs in areas with poor sanitation and pig management practices. When this parasite infects the human brain, it can cause epilepsy or severe headaches. Our study aimed to measure the association between being seropositive to cysticercal antigens and having epilepsy (lifetime and active) or severe headaches in 60 villages of Burkina Faso. We found that active epilepsy and severe headaches were associated with seropositivity to cysticercal antigens. These results confirm prior studies which suggested an association between being seropositive for cysticercal antigens and these two neurological symptoms. Preventing cysticercosis could reduce new cases of these two neurological symptoms from occurring.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b86021260d985429000539d27f8f54 https://doaj.org/article/24c5ec91eaa4474d8d9a3f2aee3dea08 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.