Expression of Matrix Metalloproteinase-10 in Renal Cell Carcinoma and Its Prognostic Role
| Autor: | Masaharu Nishikido, Shigeru Kanda, Yasuyoshi Miyata, Hiroshi Kanetake, Takahisa Iwata, Sugure Maruta, Shigehiko Koga |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Proliferation index Angiogenesis Urology Matrix Metalloproteinase 10 Renal cell carcinoma Biomarkers Tumor medicine Carcinoma Humans Carcinoma Renal Cell Survival rate Aged Cell Proliferation Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Middle Aged Prognosis medicine.disease Immunohistochemistry Kidney Neoplasms Survival Rate Cancer cell Disease Progression Female business Kidney cancer Follow-Up Studies |
| Zdroj: | European Urology. 52:791-797 |
| ISSN: | 0302-2838 |
| DOI: | 10.1016/j.eururo.2006.12.028 |
| Popis: | Matrix metalloproteinase (MMP)-10 is associated with malignant aggressiveness in various cancers, but its importance has not been investigated in conventional renal cell carcinoma (CRCC). The purpose of this study was to determine the clinical significance and malignant potential of MMP-10 in human CRCC tissues.Specimens were obtained from 103 CRCC patients who underwent radical surgery and were examined by immunohistochemistry for MMP-10 expression. The proportions of Ki-67-stained cells (proliferation index: PI) and densities of CD34-positive vessels (microvessel density: MVD) were measured by a computer-aided image analysis system. The relationships between MMP-10 expression and clinicopathologic features and various parameters including tumour size, PI, MVD, and survival were investigated by univariate and multivariate analyses.MMP-10 expression was mainly detected in cancer cell cytoplasm, and 45 (43.7%) CRCCs were considered MMP-10-positive. MMP-10 expression correlated with grade (p=0.006) and pT stage (p0.001), and it was a significant and independent factor for high pT stage in multivariate analysis model. MMP-10 expression was associated with MVD (p = 0.022) but not tumour size or PI. MMP-10 expression in CRCC was a significant predictor of poor outcome by log-rank test (p = 0.013) but not by multivariate analysis.MMP-10 seems to play an important role in renal cancer cell invasion and is a potentially useful therapeutic target to prevent CRCC tumour progression. |
| Databáze: | OpenAIRE |
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