The effects of tranexamic acid on blood loss and transfusion rate in colorectal surgery
| Autor: | Signe Braafladt, Jasim Alabbad, Marianne Huebner, Scott R. Kelley, Kellie L. Mathis, Fabian Grass, Jenna K. Lovely, David W. Larson |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Aged Antifibrinolytic Agents/therapeutic use Blood Loss Surgical/prevention & control Blood Loss Surgical/statistics & numerical data Blood Transfusion/statistics & numerical data Colectomy Drug Administration Schedule Female Hemostasis Surgical/methods Humans Intraoperative Care/methods Middle Aged Patient Safety Pilot Projects Proctectomy Retrospective Studies Tranexamic Acid/therapeutic use Treatment Outcome Colorectal surgery Patient outcomes Tranexamic acid Transfusion rate medicine.medical_specialty Blood Loss Surgical 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Hemoglobin drop Blood loss Medicine Blood Transfusion 030212 general & internal medicine Intraoperative Care business.industry Retrospective cohort study General Medicine Single surgeon Antifibrinolytic Agents Hemostasis Surgical Tranexamic Acid Anesthesia Cohort Surgery business medicine.drug |
| Zdroj: | American journal of surgery, vol. 218, no. 5, pp. 876-880 |
| Popis: | Background The present study aimed to evaluate safety of tranexamic acid (TA) administration and to assess bleeding risk in colorectal surgery (CRS). Methods Retrospective cohort study including consecutive patients undergoing elective CRS by a single surgeon between August 2014 and May 2015. All patients received 1 g of TA intravenously at induction and at closure. Demographics, operative and postoperative details were prospectively assessed and compared to a historical control cohort. Results 213 patients were evaluated. TA did not increase complications, readmissions, or reoperation rates. Significant postoperative hemoglobin (Hgb) drop (≥3 g/dL) (TA: n = 6, 7.4%, Control: n = 22, 16.6%; p = 0.193) and transfusion rates (intraoperative: TA: n = 2, 2.5%, Control: n = 2, 1.5%; p = 0.586, postoperative: TA: n = 1, 1.2%, Control: 9, 6.8%; p = 0.065) were not statistically different. Conclusions Postoperative hemoglobin drop and transfusion rates were not decreased statistically. Further study is warranted given the large clinical differences in favor of TA. |
| Databáze: | OpenAIRE |
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