Glutathione S-transferase activity in the liver in acute pancreatitis at various terms of disease and during treatment with inducers
| Autor: | N. V. Prokop'eva, L. F. Gulyaeva |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Time Factors General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Internal medicine medicine Animals Inducer Rats Wistar Glutathione Transferase chemistry.chemical_classification biology business.industry General Medicine Glutathione medicine.disease Rats Up-Regulation Glutathione S-transferase Enzyme Endocrinology chemistry Liver Pancreatitis Acute Disease biology.protein Acute pancreatitis Phenobarbital business Drug metabolism medicine.drug |
| Zdroj: | Bulletin of experimental biology and medicine. 129(5) |
| ISSN: | 0007-4888 |
| Popis: | Glutathione S-transferase activity increased in rats with acute pancreatitis: 2.2 times on day 2, 2-fold on day 4, and 1.5 times on day 10. Inducers of microsomal enzymes aroclor 1254 and phenobarbital notably inhibited glutathione S-transferase activity in animals with experimental pancreatitis on days 2–4 of the disease (3.1–2.5 times in comparison with sham-operated induced animals). Hence, the activity of enzymes of phase II of liver xenobiotic metabolism is altered in acute pancreatitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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