MYEOV gene overexpression in primary plasma cell leukemia with t(11;14)(q13;q32)
| Autor: | Cosimo Cumbo, Paola Orsini, Crescenzio Francesco Minervini, Elisa Parciante, Giorgina Specchia, Angelo Cellamare, Claudia Brunetti, Antonella Zagaria, Anna Mestice, Luciana Impera, Luisa Anelli, Angela Minervini, Giuseppina Tota, Nicoletta Coccaro, Francesco Albano, Paola Casieri |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Plasma cell leukemia Cancer Research biology Breakpoint Plasma cell dyscrasia Articles Cell cycle medicine.disease Molecular biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Cyclin D1 Oncology 030220 oncology & carcinogenesis hemic and lymphatic diseases medicine biology.protein Gene Multiple myeloma Immunoglobulin heavy locus |
| Popis: | Primary plasma cell leukemia (pPCL) is an uncommon form of plasma cell dyscrasia, and the most aggressive of the human monoclonal gammopathies. The t(11;14)(q13;q32) rearrangement is the most common alteration in pPCL, promoting cyclin D1 (CCND1) gene overexpression caused by its juxtaposition with the immunoglobulin heavy locus chromosome region. The myeloma overexpressed (MYEOV) gene maps very close to the CCND1 gene on chromosome 11, but its overexpression is rarely observed in multiple myeloma. The present study describes a case of pPCL with t(11;14) characterized by a breakpoint on der(11), unlike the one usually observed. Droplet digital polymerase chain reaction analysis revealed overexpression of CCND1 and MYEOV. To the best of our knowledge, MYEOV gene overexpression has never been previously described in pPCL. |
| Databáze: | OpenAIRE |
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