A new HA/TTCP material for bone augmentation: an in vivo histological pilot study in primates sinus grafting
| Autor: | Francesco Bucciotti, Alberto Rebaudi, Robotti Pierfrancesco, Marzio Piccinini, Vincenzo M. Sglavo |
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| Rok vydání: | 2013 |
| Předmět: |
Calcium Phosphates
BALB 3T3 Cells Bone Regeneration Bone density Maxillary sinus Dentistry Bone Matrix Sinus Floor Augmentation Pilot Projects chemistry.chemical_compound Mice X-Ray Diffraction Bone Density Osseointegration Osteogenesis medicine Maxilla Animals Bone regeneration Sinus (anatomy) business.industry Biomaterial Tetracalcium phosphate ttcp Membranes Artificial Macaca fascicularis medicine.anatomical_structure Durapatite chemistry Bone Substitutes Models Animal Bone Trabeculae Microscopy Electron Scanning Bone Remodeling Collagen Oral Surgery business Porosity |
| Zdroj: | Implant dentistry. 22(1) |
| ISSN: | 1538-2982 |
| Popis: | OBJECTIVE Synthetic calcium phosphate bone substitutes are widely used in sinus graft procedures due to their osteoconductive and biocompatible properties. Hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP), and HA/β-TCP composite are the most applied materials. The aim of this study was to propose a new mineralogical formulation, HA/tetracalcium phosphate (TTCP), as biomaterial for bone regeneration in the maxillary sinus. METHODS Sinus grafts were performed by using granules of a HA/TTCP blend and a collagen membrane. Bone response at time points of 14 and 17 weeks was histologically evaluated. RESULTS After 14 weeks of healing, histomorphometric analysis showed the formation of new bone trabeculae among HA/TTCP granules. After 17 weeks, the bone trabeculae were thicker and HA/TTCP granules were still present. Histomorphometric analysis revealed a bone graft contact (BGC) of 64%. CONCLUSIONS After 17 weeks from implantation, HA/TTCP synthetic bone graft performed very well as osteoconductive material: BGC was found very high, and bone volume and vital bone showed an ideal bone density for implant placement. HA/TTCP granules are accounted for to accelerate new bone formation and to reduce the time needed for the graft healing, thus achieving high quantity of the new bone formed. |
| Databáze: | OpenAIRE |
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