Responses of Rat Lungs to Low Lung Burdens of Inhaled Beryllium Metal
| Autor: | Gregory L. Finch, M. B. Snipes, Mark D. Hoover, R.G. Cuddihy, Patrick J. Haley |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pathology
medicine.medical_specialty Lung Inhalation medicine.diagnostic_test business.industry Pulmonary toxicity Health Toxicology and Mutagenesis Respiratory disease respiratory system Toxicology medicine.disease respiratory tract diseases Beryllium Metal medicine.anatomical_structure Bronchoalveolar lavage Toxicity Medicine Toxicokinetics business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1091-7691 0895-8378 |
| DOI: | 10.3109/08958379408995232 |
| Popis: | The linkage between acute and chronic toxic responses to inhaled beryllium (Be) is not well understood. This study described (1) the lowest lung burdens of Be that would induce acute pulmonary toxicity, (2) the progression of acute to chronic toxic responses, and (3) the effects of Be exposure on lung clearance. We simultaneously exposed groups of male F344/N rats by single, brief, nose-only inhalation to a mixed aerosol consisting of Be metal and radioactive tracer particles. Lung burdens of Be achieved were 0.32, 1. B, 10, and 100 μg; control rats received the tracer particles alone. The purpose of the tracer particle exposure was to compare lung clearance of these particles between groups. Groups of rats were sacrificed at 8, 16, 40, 90, 210, and 365 days after exposure for histopathologic examination and for bronchoalveolar lavage. No lesions were observed in controls or in animals receiving lung burdens of 0.32 μg Be. At the 1.8 μg lung burden of Be, only late-occurring, minimal chronic infla... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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