Increased expression of focal adhesion kinase in thyroid cancer: immunohistochemical study
| Autor: | Yeo Joo Kim, Ji Sung Yoon, Sang Jin Kim, So Young Jin, Myung Hi Yoo, Chul Hee Kim, Yong-Jin Lee, Dong Won Byun, Hyeong Kyu Park, Jin Woo Park, Ji O Mok, Kyo Il Suh |
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| Rok vydání: | 2004 |
| Předmět: |
Adenoma
Adult Male Pathology medicine.medical_specialty endocrine system Biology medicine.disease_cause Focal adhesion Protein-Tyrosine Kinase medicine Carcinoma Biomarkers Tumor Humans Thyroid Neoplasms Thyroid Nodule Thyroid cancer Aged Focal Adhesions Thyroid General Medicine Hyperplasia Middle Aged Protein-Tyrosine Kinases medicine.disease Immunohistochemistry Carcinoma Papillary Focal Adhesion Kinase medicine.anatomical_structure Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases Cancer research Female Original Article biological phenomena cell phenomena and immunity Carcinogenesis |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1011-8934 |
| Popis: | Focal adhesion kinase (FAK) is a tyrosine kinase that is found in cellular structures called focal adhesions. FAK appears to be a key element in signal transduction pathways involved in cell adhesion and locomotion. FAK is overexpressed in various tumors, including tumors derived from regions of the head and neck, colon, breast, prostate, and liver. In this study, we investigated immunohistochemically whether FAK expression was increased in thyroid cancers. FAK staining was not seen in any of the 20 normal thyroid tissues or the 6 nodular hyperplasia specimens. In contrast, FAK staining was observed in all of 17 papillary carcinomas, 9 follicular carcinomas, 8 medullary carcinomas, and 2 anaplastic carcinomas. Nine of 17 follicular adenomas showed FAK immunoreactivity. FAK was not expressed in normal tissue and nodular hyperplasia, but was expressed in some of the follicular adenoma, and all of the follicular, papillary, medullary and anaplastic thyroid carcinoma. This result indicates that the up-regulation of FAK may play a role in the development of thyroid carcinogenesis. |
| Databáze: | OpenAIRE |
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