Methodological Study of Vancomycin Dosing in Elderly Patients Using Actual Serum Creatinine Versus Rounded Serum Creatinine
| Autor: | Stephanie Baumhover, Matt Daniel, Tramaine Young, Jane Green, Duke Eidson |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Vancomycin Dose Urology Renal function behavioral disciplines and activities 030226 pharmacology & pharmacy Mean difference 03 medical and health sciences chemistry.chemical_compound Sex Factors 0302 clinical medicine Vancomycin Humans Medicine Drug Dosage Calculations Original Research Article 030212 general & internal medicine Dosing Aged Retrospective Studies Aged 80 and over Pharmacology Creatinine business.industry Age Factors Confidence interval Anti-Bacterial Agents Surgery chemistry Female Methodological study business medicine.drug |
| Zdroj: | Drugs in R&D |
| ISSN: | 1179-6901 1174-5886 |
| DOI: | 10.1007/s40268-017-0200-1 |
| Popis: | Purpose The practice of intentional rounding up of serum creatinine (SCr) in elderly patients with low measured values can lead to an underestimation of creatinine clearance and subsequent inaccurate dosing of medications. Thus, the purpose of this study was to evaluate the accuracy of vancomycin dose calculations for patients aged ≥65 years using an SCr rounded up to 1 mg/dL versus actual SCr. Methods This study compared the difference between measured steady-state vancomycin trough concentrations with predicted trough concentrations that have been calculated using rounded SCr and actual SCr. All non-obese patients ≥65 years of age with a baseline SCr |
| Databáze: | OpenAIRE |
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