| Autor: |
Zheng Wu, Jinhua Lan, Xipei Wang, Yijin Wu, Fen Yao, Yifan Wang, Bo-xin Zhao, Yirong Wang, Jingchun Chen, Chunbo Chen |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Antimicrobial agents and chemotherapy. 66(5) |
| ISSN: |
1098-6596 |
| Popis: |
The effect of heart transplantation (HTx) on the pharmacokinetics (PK) of caspofungin is not well-characterized. The aim of this study was to investigate the population PK of caspofungin in HTx and non-HTx patients and to identify covariates that may affect the PK of caspofungin. Seven successive blood samples were collected before administration and at 1, 2, 6, 10, 16, and 24 h after the administration of caspofungin for at least 3 days. This study recruited 27 HTx recipients and 31 non-HTx patients with 414 plasma concentrations in total. A nonlinear mixed-effects model was used to describe the population PK of caspofungin. The PK of caspofungin was best described by a two-compartment model. The clearance (CL) and volume of the central compartment ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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