The effect of water and shampooing on the efficacy of fluralaner spot-on solution against Ixodes ricinus and Ctenocephalides felis infestations in dogs
| Autor: | Anja Regina Heckeroth, Rainer K. A. Roepke, Janina Taenzler, Eva Zschiesche, Boyd Gale |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Bathing
Male Veterinary medicine Flea Fluralaner Insecticides Administration Topical Ixodes ricinus Beagle 0403 veterinary science chemistry.chemical_compound 0302 clinical medicine Dog Dog Diseases Acaricides biology 04 agricultural and veterinary sciences Ctenocephalides felis Pharmaceutical Solutions Infectious Diseases Treatment Outcome Female Tick Efficacy 040301 veterinary sciences Skin Absorption 030231 tropical medicine Bravecto™ spot-on solution Soaps 03 medical and health sciences Dogs Flea Infestations parasitic diseases Animals Shampooing Ctenocephalides Water-immersion Ixodes Acaricide Research Water Baths Isoxazoles biology.organism_classification bacterial infections and mycoses Tick Infestations chemistry Parasitology |
| Zdroj: | Parasites & Vectors |
| ISSN: | 1756-3305 |
| Popis: | Background Fluralaner spot-on solution provides immediate and persistent efficacy against tick and flea infestations in dogs and cats for 12-weeks following topical administration. The active ingredient fluralaner is distributed systemically following transdermal absorption. Therefore, this study tested the hypothesis whether water-immersion or shampooing of dogs following administration of fluralaner spot-on solution has an impact on subsequent tick and flea efficacy. Methods Thirty-two Beagle dogs were allocated to four study groups of 8 dogs each. On day 0, dogs in the 2 treatment groups received topical administration of fluralaner (Bravecto™ spot-on solution) according to label instructions. Dogs in the 2 corresponding control groups remained untreated. On days 3, 21, 49, and 77 dogs in one treatment group and control group were water-immersed for 2–5 min, while dogs in the other treatment group and control group were shampooed 6–8 min with a commercial foaming micro-emulsion, unscented product. On days 4, 28, 56, and 84 all dogs were co-infested with 50 ± 2 female and 10 ± 2 male Ixodes ricinus and 100 ± 4 Ctenocephalides felis, with tick and flea removal and counts 48 ± 2 h post-infestation. Efficacy against ticks and fleas was calculated for each assessment time point. Results No treatment-related adverse event was observed in any of the 16 dogs treated with fluralaner spot-on solution during the study. Efficacy against ticks at each assessment time point was between 99.7 and 100 % in the water-immersed group and between 99.2 and 100 % in the shampooed group. Efficacy against fleas was 100 % at each assessment time point as well in the water-immersed as the shampooed group. Tick and flea reduction in both treatment groups was significant at all assessment time points (p |
| Databáze: | OpenAIRE |
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