Investigating the potential disease-modifying and neuroprotective efficacy of exercise therapy early in the disease course of multiple sclerosis: The Early Multiple Sclerosis Exercise Study (EMSES)
Autor: | Morten Riemenschneider, Lars G Hvid, Steffen Ringgaard, Mikkel Karl Emil Nygaard, Simon Fristed Eskildsen, Tobias Gaemelke, Melinda Magyari, Henrik Boye Jensen, Helle Hvilsted Nielsen, Matthias Kant, Masoud Falah, Thor Petersen, Egon Stenager, Ulrik Dalgas |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | Riemenschneider, M, Hvid, L G, Ringgaard, S, Nygaard, M K E, Eskildsen, S F, Gaemelke, T, Magyari, M, Jensen, H B, Nielsen, H H, Kant, M, Falah, M, Petersen, T, Stenager, E & Dalgas, U 2022, ' Investigating the potential disease-modifying and neuroprotective efficacy of exercise therapy early in the disease course of multiple sclerosis : The Early Multiple Sclerosis Exercise Study (EMSES) ', Multiple sclerosis (Houndmills, Basingstoke, England), vol. 28, no. 10, pp. 1620-1629 . https://doi.org/10.1177/13524585221079200 |
ISSN: | 1477-0970 1352-4585 |
Popis: | Background: Potential supplemental disease-modifying and neuroprotective treatment strategies are warranted in multiple sclerosis (MS). Exercise is a promising non-pharmacological approach, and an uninvestigated ‘window of opportunity’ exists early in the disease course. Objective: To investigate the effect of early exercise on relapse rate, global brain atrophy and secondary magnetic resonance imaging (MRI) outcomes. Methods: This randomized controlled trial ( n = 84, disease duration Results: No between-group differences were observed for primary outcomes, relapse rate (incidence-rate-ratio exercise relative to control: (0.49 (0.15; 1.66), p = 0.25) and global brain atrophy rate (−0.04 (−0.48; 0.40)%, p = 0.87), or secondary measures of lesion load. Aerobic fitness increased in favour of the exercise group. Microstructural integrity was higher in four of eight a priori defined motor-related tracts and nuclei in the exercise group compared with the control (thalamus, corticospinal tract, globus pallidus, cingulate gyrus) at 48 weeks. Conclusion: Early supervised aerobic exercise did not reduce relapse rate or global brain atrophy, but does positively affect the microstructural integrity of important motor-related tracts and nuclei. |
Databáze: | OpenAIRE |
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