Investigating the potential disease-modifying and neuroprotective efficacy of exercise therapy early in the disease course of multiple sclerosis: The Early Multiple Sclerosis Exercise Study (EMSES)

Autor: Morten Riemenschneider, Lars G Hvid, Steffen Ringgaard, Mikkel Karl Emil Nygaard, Simon Fristed Eskildsen, Tobias Gaemelke, Melinda Magyari, Henrik Boye Jensen, Helle Hvilsted Nielsen, Matthias Kant, Masoud Falah, Thor Petersen, Egon Stenager, Ulrik Dalgas
Rok vydání: 2022
Předmět:
Zdroj: Riemenschneider, M, Hvid, L G, Ringgaard, S, Nygaard, M K E, Eskildsen, S F, Gaemelke, T, Magyari, M, Jensen, H B, Nielsen, H H, Kant, M, Falah, M, Petersen, T, Stenager, E & Dalgas, U 2022, ' Investigating the potential disease-modifying and neuroprotective efficacy of exercise therapy early in the disease course of multiple sclerosis : The Early Multiple Sclerosis Exercise Study (EMSES) ', Multiple sclerosis (Houndmills, Basingstoke, England), vol. 28, no. 10, pp. 1620-1629 . https://doi.org/10.1177/13524585221079200
ISSN: 1477-0970
1352-4585
Popis: Background: Potential supplemental disease-modifying and neuroprotective treatment strategies are warranted in multiple sclerosis (MS). Exercise is a promising non-pharmacological approach, and an uninvestigated ‘window of opportunity’ exists early in the disease course. Objective: To investigate the effect of early exercise on relapse rate, global brain atrophy and secondary magnetic resonance imaging (MRI) outcomes. Methods: This randomized controlled trial ( n = 84, disease duration Results: No between-group differences were observed for primary outcomes, relapse rate (incidence-rate-ratio exercise relative to control: (0.49 (0.15; 1.66), p = 0.25) and global brain atrophy rate (−0.04 (−0.48; 0.40)%, p = 0.87), or secondary measures of lesion load. Aerobic fitness increased in favour of the exercise group. Microstructural integrity was higher in four of eight a priori defined motor-related tracts and nuclei in the exercise group compared with the control (thalamus, corticospinal tract, globus pallidus, cingulate gyrus) at 48 weeks. Conclusion: Early supervised aerobic exercise did not reduce relapse rate or global brain atrophy, but does positively affect the microstructural integrity of important motor-related tracts and nuclei.
Databáze: OpenAIRE
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