Liver disease in anti-hepatitis C virus-positive Norwegian blood donors
| Autor: | E. Schrumpf, Orjasaeter H, J. C Siebke, O Flesland, K. Elgjo, J. Andersen Glende, I. Nordøy |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Substance-Related Disorders Hepatitis C virus Immunoblotting Molecular Sequence Data Blood Donors Enzyme-Linked Immunosorbent Assay Hepacivirus medicine.disease_cause Polymerase Chain Reaction Virus law.invention Flaviviridae Liver disease law medicine Humans Hepatitis Antibodies Prospective Studies Polymerase chain reaction Hepatitis Chronic biology medicine.diagnostic_test Base Sequence business.industry Norway Liver Diseases Gastroenterology Alanine Transaminase Hepatitis C Middle Aged medicine.disease biology.organism_classification Virology Liver biopsy RNA Viral Female Viral disease business |
| Zdroj: | Scandinavian journal of gastroenterology. 29(1) |
| ISSN: | 0036-5521 |
| Popis: | In a prospective study of 16,756 consecutive blood donors, we found 54 donors (0.3%) to be anti-hepatitis C virus (HCV)-positive by a first-generation enzyme-linked immunosorbent assay. After retesting, 18 donors were confirmed positive or indeterminate by a second-generation recombinant immunoblot assay. Sixteen of these donors were found positive by a second-generation enzyme-linked immunosorbent assay, and 15 of these were positive by HCV polymerase chain reaction with two primer sets. Nine donors (50%) had a history of drug abuse. In 15 donors found positive by a second-generation enzyme-linked immunoblot assay liver biopsy specimens were taken after at least 6 months' follow-up. In all except one hepatitis C RNA-negative donor, histologic abnormalities were observed, even when alanine aminotransferase (ALAT) levels were continuously normal or only moderately elevated. The abnormalities were less pronounced in these donors (n = 5) than in donors with ALAT levels increased more than twice the upper normal limit (p0.05). In conclusion, we found the proportion of previous drug abusers in anti-HCV-positive blood donors to be high. We confirm that the presence of anti-HCV (second generation) usually, and HCV-RNA always, seems to indicate ongoing infection--also when ALAT levels are normal. Our study further suggests that low-activity hepatitis, evaluated by ALAT levels, may indicate a milder disease. |
| Databáze: | OpenAIRE |
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